{"id":"W3123153443","doi":"10.1172/jci138267","title":"Impaired complex I repair causes recessive Leber’s hereditary optic neuropathy","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Lomonosov Moscow State University; Università di Bologna; Cardio-Pulmonary Institute; Ministero della Salute; E-Rare; Austrian Science Fund; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Deutsche Forschungsgemeinschaft","keywords":"Medicine; Leber's hereditary optic neuropathy; Optic neuropathy; Genetics; Biology; Ophthalmology; Optic nerve","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007808614,0.000111958,0.0003177439,0.00003751868,0.00005839725,0.00001951397,0.000113613,0.0002224173,0.0001155986],"category_scores_gemma":[0.004721655,0.00009849505,0.0003405059,0.0001138167,0.0001646959,0.00001313863,0.00005737571,0.0002949792,0.00001605249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000832776,"about_ca_system_score_gemma":0.0004256392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002952934,"about_ca_topic_score_gemma":0.00001636182,"domain_scores_codex":[0.9976491,0.0007238432,0.001083188,0.0002342667,0.0001805158,0.0001290742],"domain_scores_gemma":[0.9981315,0.0001519786,0.0006632115,0.0002441803,0.0005840713,0.0002251219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006426417,0.0002642274,0.05318878,0.00004446529,0.0002370062,0.0009544294,0.0001058212,0.0003475702,0.7791589,0.0002323692,0.1625215,0.002302347],"study_design_scores_gemma":[0.007590072,0.008137045,0.3677036,0.0002723292,0.0005502081,0.007621139,0.0006483428,0.001365004,0.2539851,0.004530058,0.3466451,0.0009519485],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937711,0.0004198722,0.0007342978,0.001633665,0.00300924,0.00006052178,0.0000067076,0.00001215526,0.0003524408],"genre_scores_gemma":[0.9609503,0.0006319531,0.02267581,0.007324371,0.006892987,0.000003695859,0.0001912155,0.00003451202,0.001295204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5251738,"threshold_uncertainty_score":0.5652603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09276138396998931,"score_gpt":0.3604003447147002,"score_spread":0.2676389607447108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}