{"id":"W3123153443","doi":"10.1172/jci138267","title":"Impaired complex I repair causes recessive Leber’s hereditary optic neuropathy","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Lomonosov Moscow State University; Università di Bologna; Cardio-Pulmonary Institute; Ministero della Salute; E-Rare; Austrian Science Fund; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Deutsche Forschungsgemeinschaft","keywords":"Medicine; Leber's hereditary optic neuropathy; Optic neuropathy; Genetics; Biology; Ophthalmology; Optic nerve","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001134301,0.0005703692,0.0001703407,0.0003241248,0.0001608205,0.0001221026,0.0001013092,0.0001952967,0.0009669178],"category_scores_gemma":[0.000265692,0.0001263696,0.00009461812,0.0001650821,0.0002893183,0.0001070586,0.0002705173,0.0001432543,0.0001671176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000244463,"about_ca_system_score_gemma":0.0001389568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001056331,"about_ca_topic_score_gemma":0.001561306,"domain_scores_codex":[0.9998971,0.0000155759,0.00001116789,0.0000350182,0.00002093405,0.00002006402],"domain_scores_gemma":[0.9998678,0.00002904352,0.00005722601,0.0000086225,0.000007762386,0.00002950643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001531151,0.000125114,0.1200848,0.0002334827,0.000103835,0.03355718,0.0005325941,0.0004899197,0.8219042,0.0007644559,0.0006808069,0.01999247],"study_design_scores_gemma":[0.0001834055,0.002100873,0.5910053,0.0000745709,0.0002262532,0.1307141,0.0004566259,0.002483778,0.2654466,0.0007300234,0.006533508,0.0000449794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982581,0.0003984632,0.0005760152,0.00002432327,0.000004898396,0.000007143217,0.00008523858,0.00003821168,0.0006076719],"genre_scores_gemma":[0.9993353,0.0001342945,0.0002307397,0.00001057462,0.00000242282,0.00000199291,0.00004973074,0.000003973274,0.0002309432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001056331,"threshold_uncertainty_score":0.003234625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09276138396998931,"score_gpt":0.3604003447147002,"score_spread":0.2676389607447108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}