{"id":"W3123202219","doi":"10.1093/brain/awaa442","title":"Defective phosphatidylethanolamine biosynthesis leads to a broad ataxia-spasticity spectrum","year":2020,"lang":"en","type":"letter","venue":"Brain","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"UCLH Biomedical Research Centre; Medical Research Council; National Institute for Health and Care Research; Brain Research UK; Multiple System Atrophy Trust; Rosetrees Trust; Muscular Dystrophy UK; Wellcome Trust; Muscular Dystrophy Association","keywords":"Spasticity; Ataxia; Phosphatidylethanolamine; Neuroscience; Biosynthesis; Broad spectrum; Medicine; Chemistry; Physical medicine and rehabilitation; Biology; Biochemistry; Phospholipid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001121354,0.0006220643,0.001024519,0.0002590538,0.0001013738,0.00004428913,0.0003410776,0.0006038336,0.001708793],"category_scores_gemma":[0.0008008973,0.0005692176,0.0004646145,0.0005269074,0.0001204272,0.00005227679,0.0001259195,0.001402441,0.001967818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002214067,"about_ca_system_score_gemma":0.0002713862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001056216,"about_ca_topic_score_gemma":0.000009702712,"domain_scores_codex":[0.9971873,0.0001512054,0.0003935904,0.0009480076,0.000620241,0.0006996565],"domain_scores_gemma":[0.9981238,0.0005259243,0.0001710515,0.0007561559,0.00006438818,0.0003587377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003352029,0.00009538262,0.0002789836,0.0002919062,0.0004384717,0.003494304,0.0002543375,5.75727e-7,0.002460478,0.0000338111,0.989992,0.002324551],"study_design_scores_gemma":[0.001219367,0.0007606175,0.004943633,0.0004751596,0.0004343743,0.00007675277,0.00001508749,0.00002926423,0.03961775,0.0005450826,0.951206,0.000676913],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01770266,0.001130331,0.001292896,0.9747146,0.0004070271,0.001319175,0.0003930503,0.0003817371,0.002658457],"genre_scores_gemma":[0.04497594,0.00004822712,0.0004416587,0.939446,0.006435727,0.0001249542,0.0004131699,0.0001803814,0.007933932],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03878599,"threshold_uncertainty_score":0.9996759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01748763570432918,"score_gpt":0.2631165993136582,"score_spread":0.245628963609329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}