{"id":"W3123244843","doi":"10.1002/cmdc.202100018","title":"Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics**","year":2021,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Simon Fraser University; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; Structural Genomics Consortium","funders":"Innovative Medicines Initiative; Wellcome Trust; Ontario Genomics Institute; Genome Canada; Canada Foundation for Innovation; Boehringer Ingelheim","keywords":"Biochemistry; Chemotype; Rational design; Arginine; Biology; Chemistry; Amino acid; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002751925,0.0005454744,0.0003604479,0.0002690461,0.0001758874,0.0002913184,0.0005329943,0.0002945707,0.00146231],"category_scores_gemma":[0.0001707212,0.0001866022,0.0002261515,0.0002828905,0.000188588,0.0003561708,0.0002846145,0.0005676051,0.0007074855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004454715,"about_ca_system_score_gemma":0.0006647991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004356189,"about_ca_topic_score_gemma":0.00181475,"domain_scores_codex":[0.9999143,0.00001455072,0.000007079841,0.00001337547,0.00002672161,0.00002408235],"domain_scores_gemma":[0.9999409,0.000008029489,0.00001624209,0.000005044749,0.00001495882,0.00001488174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003717833,0.0004048882,0.0004527034,0.0005655821,0.00003467268,0.0006348836,0.0001006085,0.009414248,0.9272981,0.008108026,0.002344299,0.05027007],"study_design_scores_gemma":[0.0006133759,0.004107881,0.001134094,0.00007802446,0.00008607544,0.001023692,0.00005982794,0.01309568,0.9101669,0.00173607,0.06783909,0.00005930622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7504991,0.03641917,0.1685533,0.002400317,0.0005072617,0.002044037,0.002718547,0.0009738338,0.03588433],"genre_scores_gemma":[0.8860809,0.0327688,0.06923303,0.0005331524,0.00009698968,0.0005492399,0.001405429,0.00007635463,0.009256079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00146231,"threshold_uncertainty_score":0.004891932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0242941120951728,"score_gpt":0.2796530001253049,"score_spread":0.2553588880301321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}