{"id":"W3123244843","doi":"10.1002/cmdc.202100018","title":"Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics**","year":2021,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Simon Fraser University; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; Structural Genomics Consortium","funders":"Innovative Medicines Initiative; Wellcome Trust; Ontario Genomics Institute; Genome Canada; Canada Foundation for Innovation; Boehringer Ingelheim","keywords":"Biochemistry; Chemotype; Rational design; Arginine; Biology; Chemistry; Amino acid; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009189088,0.00009346266,0.0001383818,0.00001971118,0.00002753891,0.00000398289,0.00004336447,0.0001236742,0.00001209653],"category_scores_gemma":[0.00006879496,0.00009723374,0.0000446161,0.00009299957,0.0000415062,0.000002488067,0.00002988476,0.00002834051,2.138401e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003691145,"about_ca_system_score_gemma":0.0008988233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005364102,"about_ca_topic_score_gemma":0.00002480397,"domain_scores_codex":[0.9993879,0.00001423037,0.0002026447,0.0002053649,0.00008796753,0.0001019413],"domain_scores_gemma":[0.9994662,0.00004078283,0.0001206015,0.000106174,0.000230469,0.00003580602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001375373,0.00004218384,0.0001216063,0.00005921986,0.0001991484,4.972716e-8,0.0001881462,0.0001022905,0.9651339,0.00001652544,0.001200096,0.03279931],"study_design_scores_gemma":[0.0005034167,0.00003632181,0.0005577934,0.00004523017,0.00005202035,0.000002296784,0.00003255671,0.0001940347,0.9936374,0.0001023109,0.004735144,0.0001014673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9468292,0.004831437,0.04703295,0.0004868493,0.0001071449,0.0004582634,0.00001912563,0.00000791342,0.000227133],"genre_scores_gemma":[0.9623814,0.000147735,0.03677998,0.0000345636,0.0001568439,0.00007082432,0.0000523024,0.0000177606,0.0003586299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03269784,"threshold_uncertainty_score":0.3965077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0242941120951728,"score_gpt":0.2796530001253049,"score_spread":0.2553588880301321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}