{"id":"W3123261984","doi":"10.1016/j.tiv.2021.105097","title":"Transcriptomic pathway and benchmark dose analysis of Bisphenol A, Bisphenol S, Bisphenol F, and 3,3',5,5'-Tetrabromobisphenol A in H9 human embryonic stem cells","year":2021,"lang":"en","type":"article","venue":"Toxicology in Vitro","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Health Canada","funders":"","keywords":"Tetrabromobisphenol A; Bisphenol A; Bisphenol S; Bisphenol; Estrogen receptor; Chemistry; Embryonic stem cell; Estrogen; Transcriptome; Stem cell; Biology; Biochemistry; Cell biology; Gene expression; Gene; Endocrinology; Genetics; Fire retardant; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004733552,0.0004131146,0.001078849,0.0003314741,0.0001155899,0.00004043157,0.000335937,0.0002877285,0.0008108545],"category_scores_gemma":[0.00004383752,0.0003943908,0.0001752284,0.001545874,0.0005948108,0.0001887631,0.0003103564,0.0004869177,0.00001315362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000206879,"about_ca_system_score_gemma":0.00004723077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008901636,"about_ca_topic_score_gemma":0.00443259,"domain_scores_codex":[0.99681,0.0003287196,0.0007841176,0.001007252,0.0002852021,0.0007847655],"domain_scores_gemma":[0.9986363,0.0003862613,0.0002222302,0.0005296757,0.00001859792,0.0002069207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009261946,0.0005579729,0.04731915,0.00008675358,0.0001897894,0.0001931529,0.00110921,0.0005149228,0.9442226,0.00009082785,0.00006078513,0.005562254],"study_design_scores_gemma":[0.003435143,0.0003386263,0.1479363,0.00008117509,0.000524057,0.00003828482,0.001166877,0.002539125,0.842235,0.0004442368,0.0005059706,0.0007551677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966969,0.001201893,0.00001230717,0.0001719077,0.00009590304,0.0004519412,0.00006867485,0.00003623185,0.001264275],"genre_scores_gemma":[0.9983864,0.0002676532,0.0006185559,0.0001916927,0.00001501991,0.00006773515,0.00003167954,0.00003608284,0.0003851407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1019875,"threshold_uncertainty_score":0.9998508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0094189933264366,"score_gpt":0.2863002804587388,"score_spread":0.2768812871323023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}