{"id":"W3123301455","doi":"10.3390/v13020196","title":"Antiviral Activity of the G-Quadruplex Ligand TMPyP4 against Herpes Simplex Virus-1","year":2021,"lang":"en","type":"article","venue":"Viruses","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Bill and Melinda Gates Foundation","keywords":"Herpes simplex virus; Virus; Viral replication; DNA; Nucleic acid; Chemistry; Virology; Biology; In vitro; G-quadruplex; DNA replication; Cell biology; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008879384,0.0002342093,0.0001412288,0.0001363415,0.00009588758,0.0001261142,0.0001498909,0.0002007071,0.0009215556],"category_scores_gemma":[0.0001458113,0.0000603507,0.00007061772,0.00007176425,0.0001263484,0.0001200815,0.0001722786,0.0001880689,0.0001206029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001279978,"about_ca_system_score_gemma":0.0001086853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000237954,"about_ca_topic_score_gemma":0.0001699918,"domain_scores_codex":[0.9999487,0.00001993292,0.000003029711,0.000009833643,0.000009018697,0.000009461307],"domain_scores_gemma":[0.9999652,0.0000122681,0.000007346968,0.000003303142,0.000004033377,0.000007805769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001998082,0.00001957991,0.0000631743,0.00005981484,0.000005717855,0.00002788073,0.000009171992,0.0002814597,0.9969128,0.00006150094,0.00004236923,0.002316757],"study_design_scores_gemma":[0.00002267934,0.0005788496,0.0007339643,0.000004902418,0.000009642076,0.00008389233,0.000007826351,0.001676686,0.9955739,0.00004796778,0.001255237,0.000004468558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972218,0.0009064592,0.0008405877,0.00003943593,0.00001125772,0.000008760586,0.00006919123,0.0000368459,0.0008657025],"genre_scores_gemma":[0.9974771,0.0004109655,0.0009926135,0.00002786856,0.000005926496,0.00001543626,0.00008888036,0.000007018806,0.0009742268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009215556,"threshold_uncertainty_score":0.003082871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03472144938905297,"score_gpt":0.3117378075070978,"score_spread":0.2770163581180448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}