{"id":"W3123301455","doi":"10.3390/v13020196","title":"Antiviral Activity of the G-Quadruplex Ligand TMPyP4 against Herpes Simplex Virus-1","year":2021,"lang":"en","type":"article","venue":"Viruses","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Bill and Melinda Gates Foundation","keywords":"Herpes simplex virus; Virus; Viral replication; DNA; Nucleic acid; Chemistry; Virology; Biology; In vitro; G-quadruplex; DNA replication; Cell biology; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007734338,0.0001624923,0.0003048059,0.00004933538,0.0001590659,0.00002172773,0.00007281348,0.00009143727,0.00015399],"category_scores_gemma":[0.0001289471,0.0001082914,0.0001953854,0.0003811163,0.0001337029,0.0001203158,0.00009334515,0.0001263525,0.00007099588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004897903,"about_ca_system_score_gemma":0.0002056168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003794946,"about_ca_topic_score_gemma":0.0002894506,"domain_scores_codex":[0.9990332,0.00008396085,0.0002017464,0.0002381828,0.0002258563,0.0002170975],"domain_scores_gemma":[0.9991546,0.00008945182,0.00009755164,0.0004970673,0.00009642622,0.00006491657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001626809,0.002150439,0.0638564,0.0001296942,0.0005837411,0.0001305617,0.0002154726,0.000009377848,0.445344,0.0003567921,0.002078245,0.4849826],"study_design_scores_gemma":[0.000787426,0.00004957603,0.07985077,0.00007061962,0.00009746923,0.00001010598,0.00003027287,0.00001945694,0.7200303,0.0000458738,0.1989226,0.00008553164],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904623,0.0002775502,0.00002437577,0.0002808315,0.0002436616,0.0001916378,0.00008684368,0.00005350743,0.008379281],"genre_scores_gemma":[0.9976962,0.0002890196,0.0001289433,0.0009745411,0.0001127357,0.0000124456,0.00000553167,0.00002351665,0.0007570864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.484897,"threshold_uncertainty_score":0.4415994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03472144938905297,"score_gpt":0.3117378075070978,"score_spread":0.2770163581180448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}