{"id":"W3123309434","doi":"10.3390/ijms22020893","title":"Gene Methylation and Silencing of WIF1 Is a Frequent Genetic Abnormality in Mantle Cell Lymphoma","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Wnt signaling pathway; Gene silencing; Mantle cell lymphoma; Cancer research; Methylation; Biology; DNA methylation; Signal transduction; Gene expression; Cell biology; Gene; Genetics; Lymphoma; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724257,0.0002190831,0.0002005468,0.0009190461,0.0001601181,0.0002100258,0.0001726255,0.0002716204,0.0007538946],"category_scores_gemma":[0.000386343,0.0001391687,0.000136451,0.0003880541,0.0002791359,0.0001249378,0.0001856669,0.0002153618,0.0001569997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002407105,"about_ca_system_score_gemma":0.0001078933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007852797,"about_ca_topic_score_gemma":0.0009800699,"domain_scores_codex":[0.9998457,0.0000237428,0.00001485723,0.00003914615,0.00004869021,0.00002772848],"domain_scores_gemma":[0.9997558,0.00005468865,0.0001183428,0.0000257335,0.00001844068,0.0000269058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002199407,0.00001840266,0.04634606,0.00005742257,0.00002927864,0.001704371,0.0001030228,0.0001115743,0.9429917,0.0001572155,0.00007078161,0.008190231],"study_design_scores_gemma":[0.00003968333,0.0004128709,0.4669591,0.00001831357,0.000143433,0.02739753,0.0002101027,0.001721287,0.4980331,0.0003812177,0.004665755,0.00001772825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968951,0.001004042,0.001447137,0.00003100879,0.000002425075,0.00001198884,0.0001313452,0.00005875715,0.0004182376],"genre_scores_gemma":[0.9990317,0.000253929,0.0004365066,0.00001257269,0.000003486839,0.000006691983,0.00009900646,0.00000573861,0.0001503596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009190461,"threshold_uncertainty_score":0.002522051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008448836340123254,"score_gpt":0.263614432014831,"score_spread":0.2551655956747077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}