{"id":"W3123536427","doi":"10.2139/ssrn.3720296","title":"Checkpoint Inhibitor Induced Colitis is Dependent on the Microbiota and Activation of Cytotoxic Innate and Adaptive Lymphocytes","year":2020,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Cytotoxic T cell; Colitis; Innate immune system; Innate lymphoid cell; Chemistry; Immunology; Biology; Biochemistry; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001532589,0.0004418927,0.0004275222,0.0002669529,0.0001318036,0.0003925274,0.0001585848,0.0002781588,0.002613066],"category_scores_gemma":[0.0001803391,0.0001589116,0.000334211,0.00009943432,0.0002283342,0.0002454554,0.0002550658,0.0009559368,0.0005194477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002406433,"about_ca_system_score_gemma":0.0003687545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001689589,"about_ca_topic_score_gemma":0.0004199186,"domain_scores_codex":[0.9997779,0.00004319505,0.00001652931,0.00003279707,0.00004583632,0.00008368629],"domain_scores_gemma":[0.999854,0.000009068016,0.00006297861,0.00001898671,0.00001166289,0.00004331756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003272057,0.0004242883,0.001639261,0.0001808978,0.00003454663,0.0003140367,0.00002278657,0.0001064211,0.9790467,0.0003916182,0.0004359126,0.01413148],"study_design_scores_gemma":[0.001365508,0.01152356,0.2094504,0.0002181588,0.0003656505,0.004654545,0.0003369221,0.003642656,0.7480261,0.001485915,0.01888389,0.00004668544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891643,0.004221442,0.001219226,0.0003456581,0.0001726484,0.00009182659,0.0002671685,0.0001499818,0.004367803],"genre_scores_gemma":[0.9948599,0.00137561,0.0007729167,0.0001286532,0.00005629579,0.00004497649,0.0002812069,0.00002381821,0.002456615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002613066,"threshold_uncertainty_score":0.008741558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806820476119576,"score_gpt":0.2400060629587183,"score_spread":0.2219378581975225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}