{"id":"W3123631173","doi":"10.1073/pnas.2021836118","title":"PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Incisive Genetics (Canada); BC Innovation Council; University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; University of California, Irvine; Children's Hospital of Philadelphia; CHDI Foundation; National Eye Institute; Roy J. Carver Charitable Trust; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Huntington's disease; SUMO protein; DNA damage; DNA repair; Transcription (linguistics); Disease; Biology; Genetics; DNA Damage Repair; Huntingtin; DNA; Cancer research; Medicine; Gene; Ubiquitin; Internal medicine; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005473664,0.0001648262,0.00009050597,0.0001113996,0.0001039493,0.0001679164,0.00009817043,0.0001174525,0.0007642479],"category_scores_gemma":[0.00004650543,0.00005908828,0.0001089175,0.00007953425,0.0001804506,0.00009912324,0.0001164816,0.0002389528,0.0001162703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002473656,"about_ca_system_score_gemma":0.0001172608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004356599,"about_ca_topic_score_gemma":0.001250292,"domain_scores_codex":[0.9999627,0.00000427941,0.000002829831,0.00001127746,0.00001076515,0.000008190442],"domain_scores_gemma":[0.9999778,0.000001829857,0.00000747909,0.00000188964,0.000002839641,0.000008109236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007501105,0.0000100852,0.000703387,0.00001639642,0.00000416588,0.00003166743,0.000008666598,0.00004989584,0.9974457,0.0000983347,0.00001476578,0.001541844],"study_design_scores_gemma":[0.000008178186,0.0001412192,0.04795497,0.000005765201,0.00002453008,0.0002970367,0.00005063755,0.0009459687,0.9485964,0.0002396247,0.001732322,0.00000334536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968443,0.001017054,0.001018216,0.00005914301,0.00001012833,0.0000048563,0.0001739592,0.00001935545,0.0008531096],"genre_scores_gemma":[0.9970313,0.0006786047,0.0005200848,0.00002290164,0.000002615201,0.000005657153,0.0002237986,0.000004149197,0.001510757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007642479,"threshold_uncertainty_score":0.002556682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03816671888603869,"score_gpt":0.2826635661878472,"score_spread":0.2444968473018085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}