{"id":"W3123647779","doi":"10.1002/onco.13684","title":"Long-Term Pooled Safety Analysis of Palbociclib in Combination with Endocrine Therapy for Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Updated Analysis with up to 5 Years of Follow-Up","year":2021,"lang":"en","type":"article","venue":"The Oncologist","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Pfizer","keywords":"Palbociclib; Medicine; Internal medicine; Neutropenia; Breast cancer; Oncology; Adverse effect; Hazard ratio; Tolerability; Cumulative incidence; Febrile neutropenia; Cancer; Gastroenterology; Gynecology; Metastatic breast cancer; Chemotherapy; Confidence interval; Cohort","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02062067,0.001403165,0.004507411,0.001999518,0.0003126528,0.002188508,0.001133992,0.0009064082,0.002167343],"category_scores_gemma":[0.01723724,0.000811008,0.01692257,0.002925497,0.000358251,0.001212025,0.00105642,0.001310211,0.0003392638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001251196,"about_ca_system_score_gemma":0.001254164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002340579,"about_ca_topic_score_gemma":0.003410608,"domain_scores_codex":[0.9912751,0.003520619,0.001392598,0.001860943,0.001553977,0.0003968254],"domain_scores_gemma":[0.981445,0.006408588,0.007122155,0.002259788,0.002385907,0.0003785281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.1224757,0.0003391666,0.2253916,0.008855204,0.5913545,0.0003501523,0.000105611,0.005026452,0.003013264,0.0001631909,0.003988008,0.03893713],"study_design_scores_gemma":[0.01350353,0.009500249,0.4468833,0.000659653,0.5157533,0.0008081948,0.0001077304,0.003232668,0.001816398,0.0003727161,0.007242356,0.0001199693],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8244634,0.1407592,0.005284113,0.0004516004,0.0004025356,0.0007036952,0.02503319,0.0002884077,0.002613771],"genre_scores_gemma":[0.9793485,0.006227596,0.001089625,0.0004166013,0.000253592,0.0003847622,0.01153578,0.00005378016,0.0006897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02062067,"threshold_uncertainty_score":0.1090538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01612740092076149,"score_gpt":0.3158817434457096,"score_spread":0.2997543425249481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}