{"id":"W3123647779","doi":"10.1002/onco.13684","title":"Long-Term Pooled Safety Analysis of Palbociclib in Combination with Endocrine Therapy for Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Updated Analysis with up to 5 Years of Follow-Up","year":2021,"lang":"en","type":"article","venue":"The Oncologist","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Pfizer","keywords":"Palbociclib; Medicine; Internal medicine; Neutropenia; Breast cancer; Oncology; Adverse effect; Hazard ratio; Tolerability; Cumulative incidence; Febrile neutropenia; Cancer; Gastroenterology; Gynecology; Metastatic breast cancer; Chemotherapy; Confidence interval; Cohort","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002769172,0.0003400484,0.001566145,0.0005462464,0.0001082532,0.00001412987,0.0002525588,0.0000883684,0.0004684359],"category_scores_gemma":[0.00008919055,0.0002369359,0.0003267347,0.004427354,0.0004257598,0.0001750235,0.0000584869,0.000226741,0.000001047348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006555957,"about_ca_system_score_gemma":0.0002982426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009676082,"about_ca_topic_score_gemma":0.005442002,"domain_scores_codex":[0.9975629,0.0002860318,0.0006976331,0.0005781936,0.0004595155,0.0004157275],"domain_scores_gemma":[0.9970128,0.0004657038,0.0006927162,0.0005393301,0.001159875,0.0001295773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1012561,0.001687137,0.5510764,0.0001149892,0.03748628,0.00005688181,0.006944628,0.004359668,0.1884991,0.0004143239,0.00006565797,0.1080389],"study_design_scores_gemma":[0.01723526,0.002076004,0.9260155,0.0001159123,0.003551375,0.000007995188,0.001094379,0.00008162158,0.04946535,0.00003028998,0.00004791098,0.0002783849],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902962,0.0003475957,0.003732824,0.002554584,0.00006217592,0.001439737,0.00147992,0.0000435363,0.0000433974],"genre_scores_gemma":[0.9955052,0.0003688488,0.001979405,0.0002542062,0.00003875886,0.0002925017,0.001128467,0.00004849505,0.0003840915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3749391,"threshold_uncertainty_score":0.9661965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01612740092076149,"score_gpt":0.3158817434457096,"score_spread":0.2997543425249481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}