{"id":"W3123682776","doi":"10.3390/ijms22031051","title":"Pseudopeptide Amyloid Aggregation Inhibitors: In Silico, Single Molecule and Cell Viability Studies","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Waterloo","funders":"Network for Aging Research, University of Waterloo; Natural Sciences and Engineering Research Council of Canada","keywords":"Neuroprotection; In silico; Cytotoxicity; Neurodegeneration; Viability assay; Amyloid (mycology); Chemistry; Peptide; Biochemistry; Biophysics; Neurotoxicity; Cell; Pharmacology; Biology; Toxicity; In vitro; Medicine; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004818134,0.0006094591,0.001025484,0.0002473156,0.0002501269,0.0006333137,0.0005978528,0.0004956387,0.001018583],"category_scores_gemma":[0.0007914109,0.0002386343,0.0006113077,0.0003875502,0.0001757261,0.0006508383,0.0002318239,0.0009882997,0.0004169291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000621267,"about_ca_system_score_gemma":0.0003319517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002616502,"about_ca_topic_score_gemma":0.003050334,"domain_scores_codex":[0.9997538,0.00003857902,0.00001643605,0.00005597391,0.0001109784,0.00002421901],"domain_scores_gemma":[0.9996612,0.0001571544,0.00004911678,0.00001539306,0.00009362151,0.00002342724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007986306,0.001174327,0.004659987,0.003076699,0.0003666732,0.0005915904,0.0002489348,0.3844509,0.5329705,0.004726195,0.005579019,0.06135654],"study_design_scores_gemma":[0.0001308374,0.0030931,0.00220439,0.0001150218,0.0002833628,0.0003140489,0.000105941,0.5375983,0.4328945,0.001301496,0.02186208,0.00009698783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8953543,0.04543364,0.04001314,0.0008650221,0.0002708347,0.0002510563,0.004632742,0.0004773756,0.01270185],"genre_scores_gemma":[0.9444935,0.02369267,0.0253362,0.0001905785,0.00006564044,0.0002561568,0.002848802,0.00009129696,0.003025122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002616502,"threshold_uncertainty_score":0.005202591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0315758769952395,"score_gpt":0.3409001890093024,"score_spread":0.3093243120140629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}