{"id":"W3123685477","doi":"10.20944/preprints201809.0289.v1","title":"The Role of Aberrations in the Immune-inflammatory Reflex System (IRS) and the Compensatory Immune-regulatory Reflex System (CIRS) in Different Phenotypes of Schizophrenia: The IRS-CIRS Theory of Schizophrenia","year":2018,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Faculty of Medicine, Chulalongkorn University; Chulalongkorn University; Asahi Glass Foundation","keywords":"Immunology; Immune system; Tumor necrosis factor alpha; Internal medicine; Medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.006628314,0.0007688878,0.001410924,0.0003361215,0.0006298187,0.00008236771,0.004035545,0.0004611941,0.00003031277],"category_scores_gemma":[0.001108857,0.0003935221,0.0005774855,0.0005156071,0.004229639,0.0001509769,0.002645798,0.001711186,0.00003786797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00025694,"about_ca_system_score_gemma":0.000439378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000311797,"about_ca_topic_score_gemma":0.0002810997,"domain_scores_codex":[0.9891161,0.005316433,0.00258173,0.001178274,0.001170405,0.0006370555],"domain_scores_gemma":[0.9894138,0.003701085,0.002246821,0.004340006,0.0002208392,0.00007745124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"observational","study_design_scores_codex":[0.006567119,0.0005401652,0.01676786,0.002687959,0.0004167341,0.00001071955,0.02250787,0.0006508852,0.2658918,0.6818388,0.00001717203,0.002102871],"study_design_scores_gemma":[0.004486129,0.00006962998,0.7001524,0.002661085,0.0001979269,0.00003313031,0.02667197,0.001235907,0.2462166,0.01740473,0.0001812735,0.0006891972],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983915,0.004860649,0.000011099,0.0003223584,0.0007240275,0.003029471,0.00006253576,0.0001032691,0.00697159],"genre_scores_gemma":[0.9987934,0.0003165872,0.00001404947,0.00003928364,0.0001385334,0.0005384233,0.000005883647,0.0000793703,0.00007442285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6833845,"threshold_uncertainty_score":0.9998516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03906542553786534,"score_gpt":0.2847223014645693,"score_spread":0.2456568759267039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}