{"id":"W3123702139","doi":"10.1182/bloodadvances.2020002833","title":"Rapid removal of phagosomal ferroportin in macrophages contributes to nutritional immunity","year":2021,"lang":"en","type":"article","venue":"Blood Advances","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Phagosome; Phagocytosis; Cell biology; Transferrin receptor; Ferroportin; Biology; Transport protein; Innate immune system; Endocytosis; Macrophage; Transferrin; Receptor; Biochemistry; Immunology; Inflammation; Hepcidin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002262801,0.0002383546,0.0003543325,0.0001844039,0.000170431,0.0002351389,0.0002006972,0.0005919306,0.000529286],"category_scores_gemma":[0.0001456799,0.0001458616,0.0002727942,0.00007165757,0.0002445334,0.0002325706,0.0002852051,0.0004759394,0.0004421753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004140853,"about_ca_system_score_gemma":0.0002693363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003953102,"about_ca_topic_score_gemma":0.0003861543,"domain_scores_codex":[0.9998356,0.00002506795,0.00001468604,0.00003496913,0.00004004885,0.00004956403],"domain_scores_gemma":[0.9998528,0.00001705942,0.00003141373,0.00002053791,0.00003486979,0.00004322247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001384764,0.00001386152,0.0003822578,0.00002138001,0.000001539145,0.00008308957,0.00001136379,0.00001929124,0.9986005,0.00006647749,0.00002783665,0.0006339523],"study_design_scores_gemma":[0.0000423801,0.0003538861,0.03206684,0.00001627094,0.00001664446,0.0009031237,0.00009711926,0.001612082,0.9613814,0.000230018,0.003267625,0.00001271394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929484,0.002528397,0.00307074,0.0002187585,0.00004485473,0.00002936532,0.0001252986,0.00007157983,0.0009626187],"genre_scores_gemma":[0.9959838,0.0005752375,0.001436791,0.00008529278,0.00001535957,0.0000381783,0.0001462377,0.00001661712,0.001702421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005919306,"threshold_uncertainty_score":0.003004432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130705493648717,"score_gpt":0.2803678707847892,"score_spread":0.269060815848302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}