{"id":"W3123702139","doi":"10.1182/bloodadvances.2020002833","title":"Rapid removal of phagosomal ferroportin in macrophages contributes to nutritional immunity","year":2021,"lang":"en","type":"article","venue":"Blood Advances","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Phagosome; Phagocytosis; Cell biology; Transferrin receptor; Ferroportin; Biology; Transport protein; Innate immune system; Endocytosis; Macrophage; Transferrin; Receptor; Biochemistry; Immunology; Inflammation; Hepcidin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001391888,0.0001074392,0.0003565473,0.000118856,0.00003630048,0.000006601541,0.00007000902,0.00004594017,0.0002904064],"category_scores_gemma":[0.0004144162,0.0001008174,0.00007707685,0.0004031454,0.00007657002,0.00008918643,0.00004376642,0.0001148239,0.000009841072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008094047,"about_ca_system_score_gemma":0.0001287972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003002543,"about_ca_topic_score_gemma":0.00005239387,"domain_scores_codex":[0.9990066,0.00005939173,0.0003366127,0.0001892968,0.000200544,0.0002075408],"domain_scores_gemma":[0.9994439,0.00007211605,0.00006998084,0.0001920049,0.0001513906,0.00007060605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002409268,0.008541536,0.2759142,0.001768264,0.000187321,0.004669128,0.000785316,0.0001017569,0.5809454,0.01296543,0.001022784,0.1106896],"study_design_scores_gemma":[0.01089047,0.0002339122,0.360237,0.0002771636,0.0001713156,0.0003744552,0.00202326,0.000003728573,0.5462996,0.001948101,0.07732016,0.0002207438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9096286,0.08506138,0.0000659974,0.001045765,0.0001367406,0.0001809024,0.00004810108,0.00001879243,0.003813762],"genre_scores_gemma":[0.9888604,0.002849307,0.007073899,0.0005789842,0.00008256917,0.00001689046,0.0000807898,0.00001097265,0.0004461445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1104689,"threshold_uncertainty_score":0.4111215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130705493648717,"score_gpt":0.2803678707847892,"score_spread":0.269060815848302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}