{"id":"W3123730963","doi":"10.1016/j.medj.2021.01.001","title":"Cell-free DNA tissues of origin by methylation profiling reveals significant cell, tissue, and organ-specific injury related to COVID-19 severity","year":2021,"lang":"en","type":"article","venue":"Med","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Ontario Genomics; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; National Institute of Mental Health; Fonds de Recherche du Québec - Santé; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Charles and Helen Schwab Foundation; National Cancer Institute; Kenneth Rainin Foundation; Cornell University; Wellcome Trust; University of California, San Francisco; Burroughs Wellcome Fund","keywords":"DNA methylation; Coronavirus disease 2019 (COVID-19); Cell-free fetal DNA; Cell; Medicine; Progenitor cell; Disease; Internal medicine; Biology; Immunology; Pathology; Bioinformatics; Stem cell; Infectious disease (medical specialty); Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001590122,0.0003076474,0.0002692745,0.0005847731,0.0002478089,0.0004935422,0.00023923,0.0003377517,0.003015513],"category_scores_gemma":[0.0001725342,0.0002315155,0.0002862522,0.0002983695,0.000251828,0.0001967296,0.0003267403,0.0008928168,0.0008042637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000234411,"about_ca_system_score_gemma":0.0002071585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001905658,"about_ca_topic_score_gemma":0.003969888,"domain_scores_codex":[0.9997476,0.00001750883,0.00001418657,0.00009729108,0.00006079651,0.00006268179],"domain_scores_gemma":[0.9998422,0.00002018688,0.00004555035,0.00002579086,0.00002632054,0.00003997413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009423622,0.000007922029,0.001465546,0.00001324162,0.00001348853,0.00002050292,0.00002426488,0.00002138897,0.9970573,0.0000607733,0.00003838898,0.00118301],"study_design_scores_gemma":[0.000009132382,0.0001953159,0.08641616,0.000008965059,0.0000886936,0.0004639804,0.0001386037,0.0006696228,0.9092847,0.0001392492,0.002574829,0.00001076342],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721774,0.002532751,0.01628784,0.0001928064,0.00007775022,0.00005941134,0.004785505,0.0002507925,0.003635693],"genre_scores_gemma":[0.9869509,0.0008339306,0.003186872,0.00009058185,0.00001061618,0.00004971383,0.003671304,0.00007340132,0.005132734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003015513,"threshold_uncertainty_score":0.01008791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01195668367832478,"score_gpt":0.2784592143508674,"score_spread":0.2665025306725426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}