{"id":"W3123787238","doi":"10.1182/blood.2020009166","title":"Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; American Heart Association","keywords":"Annexin A1; Inflammation; Kinase; Receptor; Protein kinase B; Signal transduction; Immunology; Phenotype; Biology; Cancer research; Cell biology; Medicine; Annexin; Biochemistry; Flow cytometry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002261523,0.0001181994,0.00008667455,0.00002064515,0.0001688064,0.00004543201,0.00009151451,0.00007826387,0.00002127617],"category_scores_gemma":[0.0001204102,0.00009653721,0.00006536855,0.000137942,0.00003347215,0.000009227458,0.00009230892,0.00009604107,0.000007704857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007918262,"about_ca_system_score_gemma":0.0001037614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000119833,"about_ca_topic_score_gemma":0.00002648438,"domain_scores_codex":[0.9990383,0.0001125052,0.00020982,0.0003111393,0.0001097621,0.0002185064],"domain_scores_gemma":[0.9994686,0.000009116055,0.0000890473,0.0002865475,0.00009390134,0.00005276097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002723524,0.0002361506,0.003684073,0.00003887909,0.00001388486,0.00001423479,0.00007996111,0.000431886,0.9947928,0.0001535096,0.0001490985,0.0003783137],"study_design_scores_gemma":[0.001024717,0.0001282682,0.02312607,0.00004999147,0.00004141645,0.000006356576,0.0002282028,0.000780908,0.9681283,0.0006817234,0.005588848,0.0002152205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959805,0.002634605,0.0002596847,0.0004405394,0.00008210933,0.0002087507,0.000008474004,0.00001973266,0.0003655835],"genre_scores_gemma":[0.9984751,0.00009424256,0.0002730603,0.0001031855,0.0004608553,0.00003741967,0.0002280029,0.00001934385,0.0003087714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0266645,"threshold_uncertainty_score":0.3936673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005265096565886793,"score_gpt":0.1882164243424052,"score_spread":0.1829513277765185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}