{"id":"W3123797270","doi":"10.1007/978-981-15-1185-1","title":"Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension","year":2020,"lang":"en","type":"book","venue":"","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Medical Research Council; National Institutes of Health; Fondation du Grand défi Pierre Lavoie; Japan Heart Foundation; Fonds de Recherche en Santé Respiratoire; University College London Hospitals NHS Foundation Trust; Jikei University School of Medicine; Fondation pour la Recherche Médicale; Research Promotion Foundation; Bayer Yakuhin; Ministry of Education, Culture, Sports, Science and Technology; National Center for Research Resources; Fondation Leducq; Agence Nationale de la Recherche; University College London; British Heart Foundation; United Therapeutics Corporation; National Institute for Health and Care Research; Institut National de la Santé et de la Recherche Médicale; Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique; Gordon and Rose McAlpine Foundation for Neuroscience Research; NOVARTIS Foundation (Japan) for the Promotion of Science; National Natural Science Foundation of China; Georgia Clinical and Translational Science Alliance; Japan Agency for Medical Research and Development; Smoking Research Foundation; Novartis Foundation; University of Louisville; March of Dimes Foundation; Tokyo Women's Medical University; Kosair Charities; Yale University; American Heart Association","keywords":"Ductus arteriosus; Mechanism (biology); Pulmonary hypertension; Morphogenesis; Heart disease; Cardiology; Medicine; Transcription factor; Internal medicine; Biology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001167759,0.000478779,0.0003657889,0.0004389583,0.0003392238,0.0008589952,0.0004900355,0.0006588117,0.02103506],"category_scores_gemma":[0.0001623112,0.0001668086,0.0003061896,0.0003005333,0.0008753397,0.0009086317,0.0005316989,0.001442904,0.007706102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004806352,"about_ca_system_score_gemma":0.0004210205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004500161,"about_ca_topic_score_gemma":0.0009762434,"domain_scores_codex":[0.9999232,0.00001026208,0.00000272474,0.00001264348,0.00004309418,0.000008014545],"domain_scores_gemma":[0.9999517,0.00002361613,0.000004771407,0.000002857327,0.000007610216,0.000009397721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000831004,0.00007534134,0.0002757325,0.00101429,0.0000266313,0.001387454,0.0003410927,0.0004674213,0.02226016,0.2334786,0.4510575,0.2895327],"study_design_scores_gemma":[0.000008006335,0.00003081589,0.0004673553,0.0001397232,0.000006527933,0.002564779,0.00003577386,0.0001184684,0.0007801648,0.01520077,0.9806411,0.000006445725],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.003465495,0.4504839,0.00875693,0.01231599,0.01656611,0.00007657743,0.0002266172,0.0004699341,0.5076383],"genre_scores_gemma":[0.01588088,0.2212469,0.005199679,0.007623698,0.004658664,0.00009046429,0.0002751675,0.0001064602,0.744918],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.02103506,"threshold_uncertainty_score":0.07036936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02350479510014126,"score_gpt":0.2546429373860866,"score_spread":0.2311381422859454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}