{"id":"W3123810445","doi":"10.20944/preprints201902.0006.v1","title":"Differential Methylation in APOE Genes (Chr19; exon four; from 44,909,188 to 44,909,373) and Increased Apolipoprotein E Plasmatic Levels in Subjects with Mild Cognitive Impairment”","year":2019,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Universidad Nacional de Colombia; International Brain Research Organization; Langley Research Center; Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)","keywords":"Apolipoprotein E; Methylation; Internal medicine; DNA methylation; CpG site; Oncology; Epigenetics; Medicine; Logistic regression; Endocrinology; Psychology; Biology; Genetics; Gene; Gene expression; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001377955,0.0001744277,0.0001238843,0.0004804236,0.0001982063,0.0002276944,0.0001450694,0.0001908456,0.002195893],"category_scores_gemma":[0.0004573407,0.0001001315,0.0001267393,0.0002986382,0.0001764086,0.0000615623,0.0001673754,0.0001359005,0.000160387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003072766,"about_ca_system_score_gemma":0.000182357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01664407,"about_ca_topic_score_gemma":0.020111,"domain_scores_codex":[0.9998982,0.00001645199,0.00000980871,0.00004160213,0.00001390725,0.00002007294],"domain_scores_gemma":[0.9997777,0.00003017358,0.0001184509,0.0000104998,0.00002349625,0.00003966462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000499587,0.00002867804,0.9909047,0.00002851539,0.00004437029,0.0001343292,0.00009927661,0.0000252404,0.005470294,0.00001859425,0.00006756241,0.002678875],"study_design_scores_gemma":[0.000004040257,0.00002999704,0.9992219,0.000002588941,0.00001454086,0.0002229211,0.00003544365,0.00004948771,0.0003370634,0.00001031171,0.00007041005,0.000001191332],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993951,0.0001508086,0.00006368233,0.00001783704,0.000001382133,0.000003814743,0.0001825037,0.000002364551,0.0001825625],"genre_scores_gemma":[0.9995696,0.00003812791,0.00008189912,0.000008117057,0.000001596094,0.000002536196,0.0001495567,8.034086e-7,0.0001478264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01664407,"threshold_uncertainty_score":0.03309435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1055907044085796,"score_gpt":0.3579319716349892,"score_spread":0.2523412672264096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}