{"id":"W3123853262","doi":"10.1158/0008-5472.can-20-3108","title":"Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers","year":2021,"lang":"en","type":"review","venue":"Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; National Institute of General Medical Sciences; Cancer Research UK; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Medulloblastoma; Transcription factor; Neuroblastoma; Pediatric cancer; Biology; N-Myc; Cancer research; Bioinformatics; Computational biology; Gene; Medicine; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000571451,0.0005396781,0.0008114951,0.001261923,0.0001973039,0.0007939523,0.0006622561,0.0009352062,0.002686107],"category_scores_gemma":[0.0006474979,0.0001678314,0.0004274226,0.0007963686,0.0004152564,0.001082777,0.00052219,0.002087242,0.001236037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006769781,"about_ca_system_score_gemma":0.0007252631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009619889,"about_ca_topic_score_gemma":0.001963407,"domain_scores_codex":[0.9998356,0.00003438482,0.00001859141,0.00002659928,0.00006354728,0.00002127396],"domain_scores_gemma":[0.9997638,0.0001152686,0.00002837557,0.000008122917,0.00006491189,0.00001950157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007652348,0.00008691091,0.0001446364,0.01294211,0.00008659718,0.0001623962,0.00005970258,0.0005801735,0.002746491,0.01127941,0.0466607,0.9251744],"study_design_scores_gemma":[0.00001322354,0.00008353091,0.000326262,0.002723771,0.00005052134,0.0006243766,0.00003892707,0.0001275564,0.0006845116,0.002358823,0.9929576,0.00001100077],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001666214,0.9976317,0.0001660666,0.0006194943,0.0002902541,0.00000396974,0.00001585649,0.00001024131,0.001095888],"genre_scores_gemma":[0.001083718,0.9975088,0.0001817736,0.0003485049,0.000143862,0.000005539175,0.00002228701,0.000002026966,0.0007034284],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002686107,"threshold_uncertainty_score":0.008985937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1658787295446845,"score_gpt":0.4964361690787452,"score_spread":0.3305574395340606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}