{"id":"W3123853262","doi":"10.1158/0008-5472.can-20-3108","title":"Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers","year":2021,"lang":"en","type":"review","venue":"Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; National Institute of General Medical Sciences; Cancer Research UK; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Medulloblastoma; Transcription factor; Neuroblastoma; Pediatric cancer; Biology; N-Myc; Cancer research; Bioinformatics; Computational biology; Gene; Medicine; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000896064,0.0006989487,0.002046601,0.0007718334,0.0006528393,0.0003223864,0.0007383819,0.0002819371,0.001403689],"category_scores_gemma":[0.000432431,0.000431785,0.00128421,0.002210129,0.0002117689,0.0001588331,0.000303221,0.002733597,0.0002825519],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.007887311,"about_ca_system_score_gemma":0.01008692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002618528,"about_ca_topic_score_gemma":0.0004673582,"domain_scores_codex":[0.9928666,0.001244762,0.0006803687,0.001194113,0.002155872,0.001858335],"domain_scores_gemma":[0.9962157,0.0008175496,0.0001430657,0.001326609,0.0004653638,0.001031712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001024753,0.0002017667,0.00003263455,0.006237442,0.001644728,0.0004808473,0.0007427078,0.000008248016,0.0006467435,0.000008076648,0.005326699,0.9845676],"study_design_scores_gemma":[0.00104264,0.0005980774,0.0002439617,0.02933056,0.0006898645,0.0002289911,0.0001742884,0.000003301122,0.0004254233,0.000008450274,0.9668437,0.0004107133],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01231483,0.9807019,0.000003728432,0.0003485685,0.0002932317,0.005095809,0.0005665193,0.00008671002,0.0005887399],"genre_scores_gemma":[0.01019487,0.9839886,0.00002119473,0.0001054609,0.0007222314,0.002235007,0.0001750973,0.0002188926,0.002338633],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9841569,"threshold_uncertainty_score":0.9998134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1658787295446845,"score_gpt":0.4964361690787452,"score_spread":0.3305574395340606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}