{"id":"W3123856695","doi":"10.1200/jco.2021.39.3_suppl.230","title":"LEAP-005: A phase II multicohort study of lenvatinib plus pembrolizumab in patients with previously treated selected solid tumors—Results from the gastric cancer cohort.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Lenvatinib; Medicine; Pembrolizumab; Internal medicine; Cancer; Response Evaluation Criteria in Solid Tumors; Oncology; Cohort; Phases of clinical research; Adverse effect; Gastroenterology; Surgery; Clinical trial; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004666917,0.001938464,0.001635242,0.0005646328,0.0005898601,0.001352496,0.001075965,0.001066145,0.003909125],"category_scores_gemma":[0.001571878,0.0007959643,0.001962737,0.0005242727,0.001097182,0.00112382,0.0008075548,0.002612216,0.001054648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001324876,"about_ca_system_score_gemma":0.001968194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001150972,"about_ca_topic_score_gemma":0.001895955,"domain_scores_codex":[0.9989291,0.000567894,0.00005829202,0.0001916653,0.000104546,0.0001484498],"domain_scores_gemma":[0.998656,0.0001818456,0.0002770176,0.0001683732,0.00008550612,0.0006312419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8032912,0.09086999,0.03250305,0.0006442617,0.005235801,0.0003692435,0.000422737,0.001664431,0.01968552,0.0002211954,0.003742608,0.0413499],"study_design_scores_gemma":[0.5380022,0.392967,0.05778331,0.00004023762,0.002151621,0.0005662408,0.0001841867,0.00135765,0.002630613,0.0002028076,0.004047449,0.00006668321],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941145,0.0009748719,0.0004008493,0.0001567633,0.00006881617,0.002351849,0.001222681,0.00004938943,0.0006603382],"genre_scores_gemma":[0.9894275,0.0006534753,0.001316286,0.0006279426,0.0001494716,0.002836707,0.003689675,0.00002574656,0.001273099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004666917,"threshold_uncertainty_score":0.02468127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06305905101085445,"score_gpt":0.4187735071312949,"score_spread":0.3557144561204404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}