{"id":"W3123870022","doi":"10.1016/j.jbc.2021.100314","title":"Identification of Radil as a Ras binding partner and putative activator","year":2021,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; York University","keywords":"HRAS; Rap1; Cell biology; RHOA; KRAS; Neuroblastoma RAS viral oncogene homolog; Anti-apoptotic Ras signalling cascade; GTPase; Biology; Gene knockdown; Signal transduction; IQGAP1; Kinase; Focal adhesion; RAC1; CDC42; MAPK/ERK pathway; Gene; Biochemistry; Mutation; Scaffold protein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000167865,0.0003652657,0.0003152322,0.0005795026,0.0002793183,0.0003172495,0.0003970363,0.000467644,0.002218028],"category_scores_gemma":[0.0001821032,0.0001798648,0.0004808967,0.0003951009,0.0001663294,0.0002462704,0.0003585722,0.0004011939,0.001828883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003747631,"about_ca_system_score_gemma":0.0001928767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002612277,"about_ca_topic_score_gemma":0.0004674958,"domain_scores_codex":[0.9998618,0.00002014381,0.000009215968,0.00004217883,0.0000447086,0.00002195766],"domain_scores_gemma":[0.9999094,0.00001195707,0.00003289448,0.000008178399,0.0000145723,0.00002300416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00013303,0.00003331405,0.001041129,0.0001202111,0.00001301486,0.0003954989,0.00002019563,0.00009263182,0.9931332,0.0002110035,0.0001568865,0.004649743],"study_design_scores_gemma":[0.00003753193,0.000412029,0.0144001,0.00003349304,0.0000699539,0.003620435,0.00007790708,0.003463428,0.9481423,0.0002199129,0.02949263,0.00003029756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705812,0.01117016,0.01165683,0.0004965229,0.00005322647,0.00006258144,0.001716697,0.0003209101,0.00394186],"genre_scores_gemma":[0.9696668,0.003362036,0.01479184,0.0002805492,0.00003230307,0.00003743103,0.005221387,0.00005522286,0.006552364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002218028,"threshold_uncertainty_score":0.007420063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02802503972517753,"score_gpt":0.3042960237772215,"score_spread":0.276270984052044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}