{"id":"W3123870022","doi":"10.1016/j.jbc.2021.100314","title":"Identification of Radil as a Ras binding partner and putative activator","year":2021,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; York University","keywords":"HRAS; Rap1; Cell biology; RHOA; KRAS; Neuroblastoma RAS viral oncogene homolog; Anti-apoptotic Ras signalling cascade; GTPase; Biology; Gene knockdown; Signal transduction; IQGAP1; Kinase; Focal adhesion; RAC1; CDC42; MAPK/ERK pathway; Gene; Biochemistry; Mutation; Scaffold protein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002007185,0.00007430423,0.0002614234,0.00001961578,0.0000204738,0.000008576375,0.00004162033,0.000146313,0.0001233046],"category_scores_gemma":[0.0009325715,0.00005307063,0.000107087,0.0001234967,0.00009692919,0.0000304798,0.00002775941,0.000265552,0.000002105022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006241053,"about_ca_system_score_gemma":0.0001583188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.874575e-7,"about_ca_topic_score_gemma":1.887654e-8,"domain_scores_codex":[0.9992367,0.00003017284,0.0003708947,0.0001196742,0.0001525407,0.0000899856],"domain_scores_gemma":[0.9991362,0.00007409137,0.0003746476,0.00008661883,0.000218533,0.0001098891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001748485,0.00008755951,0.001097117,0.00005231539,0.0001026857,0.0001994002,0.00008361995,0.000002214463,0.9970717,0.00001008075,0.0001041736,0.001014284],"study_design_scores_gemma":[0.0008404612,0.0001251841,0.002532767,0.000106691,0.00006366339,0.001429753,0.0003666197,0.00001096744,0.9935927,0.0001958927,0.0006833796,0.00005194676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977288,0.0009923289,0.0001443032,0.0004282195,0.00004872841,0.00003702597,0.00000702609,0.000004897428,0.0006086571],"genre_scores_gemma":[0.9990458,0.0003209798,0.0002375783,0.00005614407,0.0001014935,0.000001221375,0.000009302951,0.000005145768,0.0002223672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003479027,"threshold_uncertainty_score":0.2164157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02802503972517753,"score_gpt":0.3042960237772215,"score_spread":0.276270984052044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}