{"id":"W3123875011","doi":"10.1172/jci129433","title":"17β-estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Actelion Pharmaceuticals; National Center for Advancing Translational Sciences; University of California, San Diego; National Institutes of Health; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; U.S. Department of Defense; American Lung Association; Eli Lilly and Company; American Heart Association; Canadian Institutes of Health Research; School of Medicine, Indiana University; U.S. Department of Veterans Affairs","keywords":"Apelin; BMPR2; Internal medicine; Endocrinology; Agonist; Downregulation and upregulation; Pulmonary hypertension; Estrogen receptor; Receptor; Estrogen; Medicine; Biology; Bone morphogenetic protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002325449,0.0002892392,0.0003297102,0.0002605715,0.0001237555,0.0002085154,0.0001797472,0.0002740653,0.001254451],"category_scores_gemma":[0.0001457659,0.0001665983,0.0004113723,0.0001274359,0.0002219431,0.0002198628,0.000235357,0.0005004766,0.0003007127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009901242,"about_ca_system_score_gemma":0.0001709714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002078688,"about_ca_topic_score_gemma":0.000301712,"domain_scores_codex":[0.9999015,0.0000212441,0.00001235716,0.00001693204,0.00002278106,0.00002510935],"domain_scores_gemma":[0.9999197,0.00001108899,0.00002187123,0.00001047391,0.000008672133,0.00002831382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001183369,0.0001484697,0.001848372,0.0001481598,0.00003745573,0.0003924525,0.00004146415,0.00008110137,0.9880158,0.0002482341,0.00009888168,0.007756233],"study_design_scores_gemma":[0.0003737564,0.002851686,0.06543251,0.00003358089,0.0001809681,0.002119213,0.0001647235,0.0009030118,0.9173002,0.0004022034,0.01022301,0.00001507892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846185,0.009740115,0.002870395,0.0003922797,0.00007520701,0.0000463504,0.000254116,0.00005877294,0.001944156],"genre_scores_gemma":[0.9857227,0.006112417,0.002434241,0.0002992943,0.0000689179,0.00008695536,0.0005087685,0.0000192535,0.004747541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001254451,"threshold_uncertainty_score":0.004196525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06334375995272004,"score_gpt":0.3517476829791693,"score_spread":0.2884039230264492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}