{"id":"W3123875011","doi":"10.1172/jci129433","title":"17β-estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Actelion Pharmaceuticals; National Center for Advancing Translational Sciences; University of California, San Diego; National Institutes of Health; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; U.S. Department of Defense; American Lung Association; Eli Lilly and Company; American Heart Association; Canadian Institutes of Health Research; School of Medicine, Indiana University; U.S. Department of Veterans Affairs","keywords":"Apelin; BMPR2; Internal medicine; Endocrinology; Agonist; Downregulation and upregulation; Pulmonary hypertension; Estrogen receptor; Receptor; Estrogen; Medicine; Biology; Bone morphogenetic protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002468983,0.0001244356,0.000515616,0.0001796985,0.0000490899,0.00002484252,0.00005121794,0.000385209,0.00009898416],"category_scores_gemma":[0.004969539,0.00009110961,0.0001206847,0.0004187642,0.0002959419,0.00019642,0.0000461121,0.001199103,0.00001126453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005648355,"about_ca_system_score_gemma":0.0004673269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001102835,"about_ca_topic_score_gemma":0.000001204043,"domain_scores_codex":[0.9971576,0.0004423845,0.001306055,0.0002664982,0.0006351296,0.0001923557],"domain_scores_gemma":[0.9978949,0.0005436852,0.0004000332,0.0001363576,0.0004272272,0.0005978246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00278585,0.001223284,0.4292011,0.0004150839,0.0003657902,0.00964508,0.00008241816,0.00001850912,0.2929811,0.0001365653,0.002513827,0.2606314],"study_design_scores_gemma":[0.005730083,0.002477295,0.9466975,0.001430849,0.0003451365,0.005483094,0.00009295432,0.01288093,0.009485927,0.005993777,0.009156153,0.000226259],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880787,0.002475779,0.0004210301,0.008440358,0.0002554252,0.0002837972,0.000001402544,0.000009805768,0.00003373058],"genre_scores_gemma":[0.9938159,0.00122997,0.003336545,0.0007929784,0.0006811951,0.000004180532,0.00002971474,0.00001700587,0.00009253181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5174965,"threshold_uncertainty_score":0.5949361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06334375995272004,"score_gpt":0.3517476829791693,"score_spread":0.2884039230264492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}