{"id":"W3123973163","doi":"10.1021/acs.bioconjchem.0c00616","title":"Multifunctional Neomycin-Triazine-Based Cationic Lipids for Gene Delivery with Antibacterial Properties","year":2021,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Politecnico di Milano; Consiglio Nazionale delle Ricerche","keywords":"Chemistry; Cationic polymerization; Transfection; Gene delivery; Triazine; Antibacterial activity; DNA condensation; Combinatorial chemistry; Cytotoxicity; Aminoglycoside; Amphiphile; Organic chemistry; Biochemistry; Bacteria; Antibiotics; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007401569,0.0002269641,0.0001749814,0.00001543704,0.00012662,0.00007194676,0.0001590361,0.0001955245,0.0001094974],"category_scores_gemma":[0.00006157242,0.0001996178,0.0001310938,0.0000716864,0.0001024,0.000007856936,0.00005649976,0.00007053522,0.00001397278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002895181,"about_ca_system_score_gemma":0.0006297247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001237798,"about_ca_topic_score_gemma":0.00001352773,"domain_scores_codex":[0.9988207,0.0000198208,0.0002346694,0.0005285763,0.0001236291,0.0002725822],"domain_scores_gemma":[0.9989163,0.0000108629,0.00009347162,0.0003940045,0.000494556,0.0000908014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008699709,0.00009686727,0.0005987461,0.0001117596,0.000103674,0.000005681272,0.000008401117,0.0001291928,0.9964701,0.00000171724,0.001213579,0.0003903121],"study_design_scores_gemma":[0.001765008,0.0001741529,0.0003595358,0.00004512135,0.00004289965,0.00004012061,0.00004352809,0.000140459,0.9734377,0.000004544814,0.0236461,0.0003008835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971468,0.0005974543,0.00118657,0.0002062774,0.000242532,0.000215866,0.0001394688,0.00002488688,0.0002401057],"genre_scores_gemma":[0.9917319,0.00009091838,0.001590514,0.0003644578,0.001153816,0.0001255227,0.002013165,0.00003502354,0.002894708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02303245,"threshold_uncertainty_score":0.814018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01696943828260387,"score_gpt":0.2190263961345643,"score_spread":0.2020569578519605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}