{"id":"W3123973163","doi":"10.1021/acs.bioconjchem.0c00616","title":"Multifunctional Neomycin-Triazine-Based Cationic Lipids for Gene Delivery with Antibacterial Properties","year":2021,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Politecnico di Milano; Consiglio Nazionale delle Ricerche","keywords":"Chemistry; Cationic polymerization; Transfection; Gene delivery; Triazine; Antibacterial activity; DNA condensation; Combinatorial chemistry; Cytotoxicity; Aminoglycoside; Amphiphile; Organic chemistry; Biochemistry; Bacteria; Antibiotics; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002177416,0.0004578917,0.0002305639,0.0002501057,0.0001098088,0.0002253789,0.000205417,0.0004837029,0.0005173218],"category_scores_gemma":[0.0002117093,0.0001373127,0.0002668839,0.0002618209,0.0002275752,0.0003257379,0.0003265575,0.000449084,0.0003825606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000336939,"about_ca_system_score_gemma":0.0002706628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003193409,"about_ca_topic_score_gemma":0.0005306526,"domain_scores_codex":[0.9998778,0.00002477008,0.00001331974,0.00002502592,0.00003509432,0.00002399967],"domain_scores_gemma":[0.9998674,0.00002029967,0.00005003178,0.00001080776,0.00002805049,0.00002332817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002396269,0.000005362567,0.00004300641,0.00004198942,0.000001932011,0.00002759246,0.000008512002,0.00006347401,0.9985827,0.00005998639,0.00001239581,0.001129114],"study_design_scores_gemma":[0.00000675003,0.00009859502,0.0003280692,0.000004485615,0.000006185027,0.000171259,0.00000634106,0.0005745375,0.9972053,0.00001779619,0.001576289,0.000004390992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9636467,0.007415133,0.0262073,0.0002570589,0.00003910341,0.0001284638,0.0002480966,0.000216664,0.00184157],"genre_scores_gemma":[0.9716178,0.00383857,0.02150911,0.0001033919,0.0000118243,0.00008534911,0.0002804784,0.00003377289,0.002519707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005173218,"threshold_uncertainty_score":0.002444744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01696943828260387,"score_gpt":0.2190263961345643,"score_spread":0.2020569578519605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}