{"id":"W3124047768","doi":"10.1002/eji.202048747","title":"Combined anti‐PD‐1 and anti‐CTLA‐4 checkpoint blockade: Treatment of melanoma and immune mechanisms of action","year":2021,"lang":"en","type":"review","venue":"European Journal of Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":196,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Cancer Research UK; Medical Research Council; National Institute for Health and Care Research; Breast Cancer Now","keywords":"Ipilimumab; Nivolumab; Pembrolizumab; Immune checkpoint; Blockade; Immune system; CTLA-4; Melanoma; Immunotherapy; Immunology; Cytotoxic T cell; Biology; Cancer research; T cell; Medicine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006842687,0.0003827524,0.003023753,0.0004136974,0.00004752079,0.00001313195,0.0001471485,0.0001564291,0.00009803988],"category_scores_gemma":[0.0000514113,0.0002677828,0.0006745103,0.0002260253,0.0002964422,0.00005235079,0.00007702057,0.0003298337,0.000001883261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001058861,"about_ca_system_score_gemma":0.000273209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001775075,"about_ca_topic_score_gemma":4.642691e-7,"domain_scores_codex":[0.9969047,0.0007670436,0.00170904,0.0002393831,0.0001732139,0.000206651],"domain_scores_gemma":[0.9970418,0.0001151337,0.002196814,0.0003623246,0.0002166503,0.00006731124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009026574,0.0004230723,0.00001921636,0.002383149,0.004857277,0.0005557589,0.0002135106,6.208659e-8,0.1134899,0.00004122603,0.00001637502,0.8770978],"study_design_scores_gemma":[0.02704096,0.03550186,0.01080978,0.04474842,0.01102015,0.03501602,0.001004596,0.000002007265,0.113248,0.0000408253,0.7206461,0.0009212337],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04090694,0.9577971,0.00005756248,0.0001304336,0.000542874,0.0003180798,0.00001749974,0.00000710104,0.0002224438],"genre_scores_gemma":[0.02270151,0.9765275,0.0004001373,0.00001010708,0.00008854815,0.000001651227,0.00002596034,0.00005985125,0.0001847144],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8761766,"threshold_uncertainty_score":0.9999774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04351420935544933,"score_gpt":0.3083278657554551,"score_spread":0.2648136564000058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}