{"id":"W3124056124","doi":"10.2139/ssrn.3595716","title":"Take a Step Down and Beware of H3K36me2: The H3K27m Mutation in Glioma Directs H3K27 Methylation","year":2020,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University and Génome Québec Innovation Centre; McGill University; McGill University Health Centre","funders":"","keywords":"Methylation; Glioma; DNA methylation; Epigenetics; Genetics; Mutation; Biology; Cancer research; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009202171,0.0008560299,0.0008156745,0.0007724425,0.002569108,0.001464631,0.00117804,0.005198694,0.0215545],"category_scores_gemma":[0.005126389,0.0005188761,0.001207369,0.0002322455,0.001508423,0.001574097,0.001760521,0.007963193,0.0154995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008617115,"about_ca_system_score_gemma":0.001827916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002524303,"about_ca_topic_score_gemma":0.007291221,"domain_scores_codex":[0.9990651,0.00007009017,0.00007741231,0.0001256753,0.0005324302,0.000129197],"domain_scores_gemma":[0.99763,0.0002826916,0.0002090493,0.0002764529,0.0005676406,0.001034128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0011344,0.0007679762,0.01036524,0.0003956874,0.000203226,0.009147787,0.0006240727,0.0002660112,0.08173129,0.002591702,0.5733435,0.3194292],"study_design_scores_gemma":[0.0004340011,0.001414536,0.02136772,0.0002702778,0.0003662873,0.02535623,0.002027501,0.0009125436,0.1297083,0.01914743,0.7986184,0.0003768308],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1086587,0.01619174,0.04117202,0.63321,0.1076161,0.0006843436,0.001107224,0.01102451,0.08033542],"genre_scores_gemma":[0.2551154,0.01117517,0.09385031,0.2407198,0.02217261,0.0004434687,0.0009389003,0.003074042,0.3725103],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0215545,"threshold_uncertainty_score":0.07210696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00812767580689115,"score_gpt":0.2404637557103594,"score_spread":0.2323360799034683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}