{"id":"W3124185217","doi":"10.3390/biomedicines9020107","title":"Breast Cancer-Derived Microvesicles Are the Source of Functional Metabolic Enzymes as Potential Targets for Cancer Therapy","year":2021,"lang":"en","type":"article","venue":"Biomedicines","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Microvesicles; Cancer cell; Cancer; Biology; Cell culture; Proteomics; Biochemistry; Breast cancer; Enzyme; Cell; Chemistry; Cell biology; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001488493,0.0002110949,0.0002647828,0.00024909,0.00009149138,0.0003864998,0.0001102867,0.0002787877,0.0004072104],"category_scores_gemma":[0.0001545462,0.00007883547,0.0002075508,0.0001902068,0.0001128956,0.0001979487,0.0001990297,0.0002928729,0.0002195241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003099121,"about_ca_system_score_gemma":0.0001471148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002645476,"about_ca_topic_score_gemma":0.0002623931,"domain_scores_codex":[0.999922,0.00001848738,0.0000046868,0.00001266403,0.0000270961,0.00001515241],"domain_scores_gemma":[0.9999439,0.00001035209,0.00001932377,0.000004497796,0.00001278198,0.000009281733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001172342,0.00001288193,0.0008737746,0.000119186,0.00001150979,0.00008256696,0.00001465269,0.0001184985,0.9886705,0.0002640097,0.0001240794,0.009591002],"study_design_scores_gemma":[0.00001462299,0.0002848615,0.009538294,0.00003658201,0.00006095475,0.001177595,0.00006559916,0.002233947,0.9648341,0.0003553797,0.02138707,0.00001106954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9153233,0.06099568,0.01890589,0.0006805669,0.00008555516,0.00006708818,0.0005954207,0.000244183,0.003102349],"genre_scores_gemma":[0.9789457,0.01325719,0.005410965,0.0001564298,0.00002468905,0.00002823108,0.000531533,0.0000232328,0.001621951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004072104,"threshold_uncertainty_score":0.002248585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01150537015011555,"score_gpt":0.2633681097459167,"score_spread":0.2518627395958011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}