{"id":"W3124229040","doi":"10.1200/jco.2021.39.3_suppl.299","title":"Zanidatamab (ZW25) in HER2-positive biliary tract cancers (BTCs): Results from a phase I study.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Medicine; Tolerability; Internal medicine; Cohort; Adverse effect; Immunohistochemistry; Trastuzumab; Oncology; Response Evaluation Criteria in Solid Tumors; Gastroenterology; Gallbladder; Chemotherapy; Surgery; Phases of clinical research; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002247714,0.0001832432,0.001935437,0.000126256,0.00004166073,0.0000133121,0.0001646145,0.0002690665,0.000154801],"category_scores_gemma":[0.005212203,0.0001400081,0.0004770811,0.000283114,0.0001350768,0.0001385791,0.0001003604,0.001466224,0.00001347667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005031656,"about_ca_system_score_gemma":0.003943784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001210003,"about_ca_topic_score_gemma":0.002549767,"domain_scores_codex":[0.9953742,0.0007318328,0.002783705,0.0003989975,0.0004335576,0.0002777131],"domain_scores_gemma":[0.9946634,0.003002037,0.00114861,0.0003257834,0.0005207117,0.0003394396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04025618,0.0245628,0.6510293,0.00002108937,0.002043414,0.05934494,0.004841405,0.00001819465,0.0003859453,0.000009443906,0.02067546,0.1968118],"study_design_scores_gemma":[0.05398976,0.01714207,0.9016731,0.000195362,0.0006662002,0.0003200578,0.004326165,0.00002833349,0.0001524125,0.00008544575,0.02128961,0.000131466],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786243,0.002548974,0.00001302784,0.0123104,0.001706026,0.0002530359,0.0001062176,0.00000813487,0.004429877],"genre_scores_gemma":[0.9930331,0.00122625,0.0006798544,0.002913742,0.001878491,0.000005673061,0.00002883736,0.00001739556,0.0002166681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2506438,"threshold_uncertainty_score":0.6996104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1374272635865832,"score_gpt":0.4865471462798224,"score_spread":0.3491198826932391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}