{"id":"W3124271884","doi":"10.2139/ssrn.3364378","title":"Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome","year":2019,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; Amgen (Canada); University of Toronto; Hospital for Sick Children","funders":"","keywords":"Rett syndrome; Key (lock); Gene; Ubiquitin; Ribosome; Neuroscience; Genetics; Psychology; Biology; Bioinformatics; Chemistry; RNA; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002810133,0.0005028704,0.0005413574,0.0004315141,0.0003637655,0.0004951431,0.0003230273,0.0008352828,0.006984151],"category_scores_gemma":[0.0005645945,0.0001963661,0.0005401696,0.0003475914,0.0004766397,0.0003091313,0.0005641537,0.000546799,0.001509232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003884162,"about_ca_system_score_gemma":0.0002691474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001071466,"about_ca_topic_score_gemma":0.001708158,"domain_scores_codex":[0.999687,0.0000391722,0.00004764468,0.00009613692,0.00007635732,0.00005365404],"domain_scores_gemma":[0.9997308,0.00006470634,0.00009112222,0.00003130493,0.00001919225,0.00006282167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001169222,0.00005862468,0.0121466,0.00009770951,0.000111345,0.002410734,0.0001102496,0.001414243,0.9706877,0.001231446,0.0005136102,0.01004851],"study_design_scores_gemma":[0.0001410395,0.001258314,0.3316976,0.000105281,0.0003248162,0.009404046,0.0006252093,0.006553334,0.6383494,0.004306561,0.007135652,0.00009882337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969182,0.0006964672,0.0007614268,0.0001652132,0.00006111311,0.000005126018,0.00035592,0.00008825232,0.0009483225],"genre_scores_gemma":[0.9983557,0.0001731369,0.0004099658,0.0001051341,0.00001078925,0.000004570104,0.000205846,0.00004077565,0.000694053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006984151,"threshold_uncertainty_score":0.02336431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005786435417217934,"score_gpt":0.235876325861099,"score_spread":0.2300898904438811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}