{"id":"W3124288694","doi":"10.1002/cbic.202000787","title":"Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class","year":2021,"lang":"en","type":"review","venue":"ChemBioChem","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Commission; European Federation of Pharmaceutical Industries and Associations; McGill University","keywords":"Trim; Chemistry; Computational biology; Protein–protein interaction; Biochemistry; Nanotechnology; Biology; Computer science; Materials science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002902275,0.0005327752,0.0007698129,0.001080898,0.0002022883,0.0006510005,0.0005212009,0.0008309924,0.002468381],"category_scores_gemma":[0.0001910001,0.0002062364,0.0002713015,0.0007534547,0.0003416637,0.001069049,0.0005118728,0.001606208,0.001903978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004129402,"about_ca_system_score_gemma":0.0004040377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002824705,"about_ca_topic_score_gemma":0.0005288997,"domain_scores_codex":[0.9999141,0.00001216377,0.000006528215,0.00001839389,0.00003442768,0.00001433884],"domain_scores_gemma":[0.9999427,0.00001756895,0.000009676558,0.000003014184,0.00001594269,0.0000111015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009511914,0.00009237666,0.0001244169,0.008561565,0.00005788816,0.0002958981,0.00005975633,0.0006264796,0.02323558,0.0132128,0.03128941,0.9223487],"study_design_scores_gemma":[0.00001305982,0.0001037046,0.0002491056,0.000669086,0.00003285484,0.001009429,0.00002738925,0.0002104593,0.004093229,0.002336052,0.9912444,0.00001126354],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006510586,0.9956601,0.0008996552,0.0004748752,0.000264779,0.00000785128,0.00002565748,0.00002975241,0.001986199],"genre_scores_gemma":[0.002693468,0.993693,0.0006953033,0.0004189504,0.0002494365,0.00001400486,0.00005401202,0.000005113451,0.002176774],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002468381,"threshold_uncertainty_score":0.008257568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04436664315624375,"score_gpt":0.3365349146555572,"score_spread":0.2921682714993135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}