{"id":"W3124312347","doi":"10.1038/s41436-020-01073-x","title":"Cystic fibrosis–related diabetes onset can be predicted using biomarkers measured at birth","year":2021,"lang":"en","type":"article","venue":"Genetics in Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; St Mary's Hospital Centre; Janeway Children's Health and Rehabilitation Centre; Foothills Medical Centre; University of Alberta Hospital; Alberta Hospital Edmonton; Kingston Health Sciences Centre; St. Michael's Hospital; St. Paul's Hospital; Izaak Walton Killam Health Centre; Alberta Children's Hospital; Institut universitaire de cardiologie et de pneumologie de Québec; Children's Hospital of Eastern Ontario; Children's Hospital of Western Ontario; Queen Elizabeth II Health Sciences Centre; BC Children's Hospital; Université Laval; Hospital for Sick Children; Université de Montréal; Children's Hospital of Winnipeg; Public Health Ontario; Royal University Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Cystic fibrosis; Cystic fibrosis-related diabetes; Cystic fibrosis transmembrane conductance regulator; Medicine; Diabetes mellitus; Internal medicine; Genome-wide association study; Bioinformatics; Gene; Endocrinology; Genotype; Type 2 diabetes; Biology; Genetics; Impaired glucose tolerance; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001142998,0.0006330925,0.0003120908,0.001144874,0.0001981791,0.0007374693,0.0002817247,0.000387901,0.002668195],"category_scores_gemma":[0.005573539,0.0001142014,0.0006792189,0.0007956166,0.0001175032,0.0001912966,0.0003559659,0.0005264748,0.0005474114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006883974,"about_ca_system_score_gemma":0.0009013205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.07592618,"about_ca_topic_score_gemma":0.08168865,"domain_scores_codex":[0.999644,0.00009997096,0.00002468478,0.00009435508,0.00009612353,0.00004078243],"domain_scores_gemma":[0.9986003,0.0007557264,0.0002748056,0.00006205454,0.0001729631,0.0001342585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003818392,0.00005191601,0.9738582,0.00003306661,0.0001296326,0.00007552539,0.00004027633,0.002638102,0.0003697795,0.00008207482,0.001211526,0.02112802],"study_design_scores_gemma":[0.00007927859,0.000226504,0.9283205,0.0001287763,0.0003345115,0.0002567402,0.0001138565,0.06677098,0.0008379261,0.0005695433,0.00232937,0.00003193117],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974574,0.001217087,0.0108754,0.0006146138,0.00006787912,0.00009143913,0.008333822,0.0004363107,0.003789436],"genre_scores_gemma":[0.9903283,0.0003579157,0.005119157,0.00006346114,0.00001682582,0.00002970658,0.003438485,0.00001627125,0.0006298829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07592618,"threshold_uncertainty_score":0.1509685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03184152008609424,"score_gpt":0.3145497504649822,"score_spread":0.282708230378888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}