{"id":"W3124312347","doi":"10.1038/s41436-020-01073-x","title":"Cystic fibrosis–related diabetes onset can be predicted using biomarkers measured at birth","year":2021,"lang":"en","type":"article","venue":"Genetics in Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; St Mary's Hospital Centre; Janeway Children's Health and Rehabilitation Centre; Foothills Medical Centre; University of Alberta Hospital; Alberta Hospital Edmonton; Kingston Health Sciences Centre; St. Michael's Hospital; St. Paul's Hospital; Izaak Walton Killam Health Centre; Alberta Children's Hospital; Institut universitaire de cardiologie et de pneumologie de Québec; Children's Hospital of Eastern Ontario; Children's Hospital of Western Ontario; Queen Elizabeth II Health Sciences Centre; BC Children's Hospital; Université Laval; Hospital for Sick Children; Université de Montréal; Children's Hospital of Winnipeg; Public Health Ontario; Royal University Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Cystic fibrosis; Cystic fibrosis-related diabetes; Cystic fibrosis transmembrane conductance regulator; Medicine; Diabetes mellitus; Internal medicine; Genome-wide association study; Bioinformatics; Gene; Endocrinology; Genotype; Type 2 diabetes; Biology; Genetics; Impaired glucose tolerance; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007825416,0.0003627971,0.0008296299,0.0004745951,0.0001407735,0.00001822064,0.00021707,0.0002207794,0.001052764],"category_scores_gemma":[0.004627045,0.0003177386,0.00009498332,0.001666417,0.000723258,0.0000382796,0.0002377525,0.0004604768,0.00000902164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006405434,"about_ca_system_score_gemma":0.0006537663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001142317,"about_ca_topic_score_gemma":0.00041912,"domain_scores_codex":[0.995829,0.0003208779,0.000843404,0.0007180125,0.001377811,0.0009109068],"domain_scores_gemma":[0.9973759,0.0006195274,0.0001550759,0.000836996,0.0004471617,0.0005653316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004163452,0.0001696004,0.2475052,0.0005940505,0.0003381164,0.0006158056,0.0006361632,0.000463082,0.7416413,0.000007468086,0.005582212,0.002030671],"study_design_scores_gemma":[0.01966639,0.002556928,0.6848706,0.006183168,0.0009491045,0.0009034397,0.001587206,0.06427543,0.1968053,0.0009281831,0.02019842,0.001075776],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981212,0.01242622,0.0001278768,0.004326754,0.0005096815,0.0006158007,0.0002161057,0.0001000577,0.0004655285],"genre_scores_gemma":[0.9858406,0.0008072332,0.01097468,0.0006150668,0.000196612,0.00003299258,0.0006741698,0.00008512888,0.000773483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.544836,"threshold_uncertainty_score":0.9999275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03184152008609424,"score_gpt":0.3145497504649822,"score_spread":0.282708230378888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}