{"id":"W3124342019","doi":"10.1139/cjm-2020-0546","title":"Repurposing of escitalopram oxalate and clonazepam in combination with ciprofloxacin and sulfamethoxazole–trimethoprim for treatment of multidrug-resistant microorganisms and evaluation of the cleavage capacity of plasmid DNA","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Microbiology","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Microbiology; Ciprofloxacin; Pharmacology; Multiple drug resistance; Antibiotics; Trimethoprim; Sulfamethoxazole; Repurposing; Biology; Chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004597782,0.00009129709,0.0003236384,0.0000820193,0.00003347206,0.000004269451,0.00004609839,0.00008631282,0.00000137732],"category_scores_gemma":[0.0001311361,0.00006441789,0.00005049726,0.00006355424,0.0002863349,0.000006749008,0.00001365877,0.00003297097,2.860528e-9],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002657486,"about_ca_system_score_gemma":0.0004151178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007418614,"about_ca_topic_score_gemma":0.006308395,"domain_scores_codex":[0.9992279,0.0001692601,0.0003416014,0.0001222905,0.00003758759,0.0001013788],"domain_scores_gemma":[0.9990554,0.00007382105,0.0004096208,0.0000981024,0.000320348,0.00004268304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000174454,0.00005601991,0.0076542,0.00007835421,0.00007685587,7.765566e-7,0.0004411066,0.00001271681,0.988816,0.00004577052,0.000009261135,0.002634489],"study_design_scores_gemma":[0.001590801,0.0005958408,0.02069103,0.00009963974,0.0001056148,0.00005390827,0.0004199608,0.00002287186,0.9759769,0.0001231747,0.0002596298,0.00006057282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956836,0.003760555,0.00004814274,0.0001083389,0.00004890365,0.0001718706,0.0001660169,1.996255e-7,0.00001237117],"genre_scores_gemma":[0.9981501,0.0002578263,0.00154142,0.00001153261,0.00001178277,0.00000166469,0.00001118832,0.00000675819,0.000007804091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01303683,"threshold_uncertainty_score":0.3520233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02105857320549821,"score_gpt":0.2401586899128965,"score_spread":0.2191001167073983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}