{"id":"W3124342019","doi":"10.1139/cjm-2020-0546","title":"Repurposing of escitalopram oxalate and clonazepam in combination with ciprofloxacin and sulfamethoxazole–trimethoprim for treatment of multidrug-resistant microorganisms and evaluation of the cleavage capacity of plasmid DNA","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Microbiology","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Microbiology; Ciprofloxacin; Pharmacology; Multiple drug resistance; Antibiotics; Trimethoprim; Sulfamethoxazole; Repurposing; Biology; Chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002112797,0.0003280024,0.0004458217,0.0003741045,0.0001139656,0.0001590857,0.0001855607,0.0001947862,0.0007262573],"category_scores_gemma":[0.0002730318,0.0001360094,0.0003568936,0.0002820806,0.0001366664,0.0001349501,0.0001754957,0.0002006052,0.0001504259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000196873,"about_ca_system_score_gemma":0.0003906387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001456854,"about_ca_topic_score_gemma":0.004118938,"domain_scores_codex":[0.999749,0.00008938491,0.00002186343,0.00002943118,0.00006723951,0.00004312655],"domain_scores_gemma":[0.9998552,0.00002999579,0.00004535592,0.00001178477,0.00002991295,0.00002771531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004509608,0.0001196343,0.0005050685,0.0001871993,0.00001878235,0.0001152669,0.00002737899,0.0001273158,0.9890851,0.00002598322,0.00003721658,0.009300099],"study_design_scores_gemma":[0.00005269601,0.004651176,0.009409494,0.00001960943,0.00008781994,0.0005320593,0.00006662968,0.0005906484,0.9827999,0.00001614801,0.001763991,0.000009727248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919572,0.005807907,0.001099239,0.00007286023,0.00002192017,0.00006354279,0.0001374469,0.00002190675,0.0008180451],"genre_scores_gemma":[0.9925713,0.002579838,0.003353508,0.00002995232,0.00001229571,0.00002515205,0.0002298337,0.000009954961,0.001188181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001456854,"threshold_uncertainty_score":0.002896726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02105857320549821,"score_gpt":0.2401586899128965,"score_spread":0.2191001167073983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}