{"id":"W3124348794","doi":"10.7554/elife.62206.sa2","title":"Author response: Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci","year":2020,"lang":"en","type":"peer-review","venue":"","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Columbia College","funders":"","keywords":"Genome-wide association study; Single-nucleotide polymorphism; Computational biology; Biology; Genetics; Evolutionary biology; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006053481,0.0008330354,0.001273749,0.001249246,0.001613577,0.003392688,0.001212498,0.005165817,0.251509],"category_scores_gemma":[0.06917685,0.0005377072,0.0005434886,0.0008657046,0.001310922,0.001530636,0.002346923,0.004645659,0.08843652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009745195,"about_ca_system_score_gemma":0.004206091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002752225,"about_ca_topic_score_gemma":0.006658654,"domain_scores_codex":[0.9961174,0.001043301,0.0002692851,0.000554378,0.001585261,0.0004304205],"domain_scores_gemma":[0.9556005,0.01696321,0.001342632,0.002381701,0.01940235,0.004309607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003552937,0.00001779431,0.001486158,0.0002748845,0.00003294224,0.0004225358,0.0002000419,0.0002665881,0.001833866,0.00414312,0.9735337,0.01743304],"study_design_scores_gemma":[0.0002650442,0.00006342518,0.00541403,0.0002425592,0.00004022252,0.000672765,0.001106165,0.001131094,0.002564992,0.01429784,0.9741018,0.00009996612],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01138087,0.001798821,0.01327824,0.5656567,0.2665354,0.000595685,0.01688617,0.003274303,0.120594],"genre_scores_gemma":[0.07551374,0.00189354,0.009713098,0.1025851,0.03310239,0.0006277557,0.01049072,0.003224051,0.7628496],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.251509,"threshold_uncertainty_score":0.8413814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06675080913217885,"score_gpt":0.3112292476839607,"score_spread":0.2444784385517818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}