{"id":"W3124348794","doi":"10.7554/elife.62206.sa2","title":"Author response: Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci","year":2020,"lang":"en","type":"peer-review","venue":"","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Columbia College","funders":"","keywords":"Genome-wide association study; Single-nucleotide polymorphism; Computational biology; Biology; Genetics; Evolutionary biology; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000479449,0.000706222,0.0008382527,0.00005724392,0.0001909858,0.00003592065,0.0005838641,0.001180173,0.01425484],"category_scores_gemma":[0.001107368,0.0005847565,0.0005230752,0.0001536821,0.0007797902,0.000002629595,0.0002029794,0.0007123045,0.0003803367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001255804,"about_ca_system_score_gemma":0.0006307269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001488872,"about_ca_topic_score_gemma":0.00004002231,"domain_scores_codex":[0.9964719,0.0004597953,0.0006533124,0.001384675,0.0004871159,0.0005432332],"domain_scores_gemma":[0.9982192,0.0002919561,0.0002809436,0.000568887,0.0002945293,0.0003445181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001615185,0.0001264396,0.00003334824,0.0002532667,0.0001492338,0.00006276628,0.000007432672,0.000004493425,0.04304268,0.00007818283,0.9528945,0.001732464],"study_design_scores_gemma":[0.000505759,0.001324894,0.0003642318,0.0006878881,0.00007672256,0.00005607738,0.000009112396,0.000005052288,0.01117359,0.00003889707,0.9850095,0.0007482718],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.03181938,0.0513282,0.003083061,0.452421,0.0112425,0.009455731,0.3061108,0.0007582227,0.1337811],"genre_scores_gemma":[0.07335204,0.005029075,0.002543536,0.04764089,0.004202754,0.0006040406,0.1474518,0.0002327774,0.7189431],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.5851619,"threshold_uncertainty_score":0.9996604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06675080913217885,"score_gpt":0.3112292476839607,"score_spread":0.2444784385517818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}