{"id":"W3124397272","doi":"10.1101/2021.01.27.428386","title":"Transcriptome profile of the zebrafish atrioventricular canal reveals molecular signatures of pacemaker and valve mesenchyme","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie","keywords":"Zebrafish; Transcriptome; Cell biology; Biology; Atrioventricular canal; Sinoatrial node; Heart development; Ectopic expression; Wnt signaling pathway; Anatomy; Internal medicine; Genetics; Gene expression; Gene; Signal transduction; Endocrinology; Medicine; Heart rate; Heart disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005269477,0.0001585892,0.0002212944,0.0003832653,0.0001970431,0.000190668,0.00008187895,0.0001961061,0.0009084334],"category_scores_gemma":[0.00007507447,0.0001334699,0.0002385738,0.0002226045,0.0001405409,0.0001334765,0.0002039508,0.0002693892,0.0002488706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001783939,"about_ca_system_score_gemma":0.0002186495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002199783,"about_ca_topic_score_gemma":0.00343601,"domain_scores_codex":[0.9999348,0.000002372157,0.000002890472,0.00002615794,0.00001931871,0.00001446674],"domain_scores_gemma":[0.9999537,0.000005262768,0.00001328356,0.000002541719,0.00001428475,0.00001086807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0000297261,0.000002805513,0.00173591,0.00003415484,0.000003234942,0.00003560294,0.00004339157,0.00005502372,0.9965821,0.00004308474,0.00004704602,0.001388028],"study_design_scores_gemma":[0.00001524374,0.0003908466,0.6845858,0.00004851078,0.0000853993,0.0005697858,0.0004783247,0.004372425,0.3007225,0.000254842,0.008431938,0.00004445966],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860327,0.001635403,0.004827709,0.00006468076,0.00002322893,0.0000290796,0.00527639,0.0001062184,0.002004549],"genre_scores_gemma":[0.9818864,0.0008540677,0.005128619,0.0001065684,0.00001196247,0.00009131305,0.005166322,0.00005905658,0.006695739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002199783,"threshold_uncertainty_score":0.004373908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007398542276928508,"score_gpt":0.2259645251737257,"score_spread":0.2185659828967972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}