{"id":"W3124401574","doi":"10.3390/cancers13030386","title":"Senolytic Targeting of Bcl-2 Anti-Apoptotic Family Increases Cell Death in Irradiated Sarcoma Cells","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Institute of Cancer Research; Cancer Research Society","keywords":"Radiation therapy; Cancer research; Apoptosis; Sarcoma; Programmed cell death; Medicine; Cancer; Cell culture; Cell; Soft tissue sarcoma; Biology; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001414343,0.000192825,0.0005192388,0.0001647197,0.00004195017,0.00001147374,0.0001067202,0.00009822955,0.000138316],"category_scores_gemma":[0.0001236453,0.0001920843,0.00009965875,0.0005990692,0.00008567973,0.00006566637,0.00003687711,0.0002185029,0.00002432028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005563346,"about_ca_system_score_gemma":0.001324167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003224039,"about_ca_topic_score_gemma":0.00008394646,"domain_scores_codex":[0.9984633,0.00008008448,0.0004245687,0.0003641529,0.0002583451,0.0004095849],"domain_scores_gemma":[0.9991164,0.0001256772,0.0001248672,0.0003171832,0.0001278654,0.0001880069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009451469,0.0001503247,0.1356568,0.0006189379,0.00004458026,0.0007448905,0.0006074854,0.0008452661,0.8584062,0.00001801643,0.001631389,0.001181578],"study_design_scores_gemma":[0.003866385,0.0002063386,0.5365707,0.0008464355,0.0001611484,0.00004284457,0.003011507,0.003313429,0.4489513,0.00002507032,0.00252681,0.0004780318],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908393,0.006806517,0.00001347396,0.00005809091,0.0002367694,0.000198102,0.00002641761,0.00004635079,0.001774977],"genre_scores_gemma":[0.9968202,0.001337727,0.0007551007,0.0004969587,0.00008851253,0.000006870924,0.000045406,0.00003263928,0.0004166045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4094549,"threshold_uncertainty_score":0.7832971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01837326336673556,"score_gpt":0.2524957273914544,"score_spread":0.2341224640247188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}