{"id":"W3124401574","doi":"10.3390/cancers13030386","title":"Senolytic Targeting of Bcl-2 Anti-Apoptotic Family Increases Cell Death in Irradiated Sarcoma Cells","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Institute of Cancer Research; Cancer Research Society","keywords":"Radiation therapy; Cancer research; Apoptosis; Sarcoma; Programmed cell death; Medicine; Cancer; Cell culture; Cell; Soft tissue sarcoma; Biology; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007920101,0.0001512137,0.0001682109,0.000123642,0.00008468279,0.0001737856,0.00007297247,0.0001150838,0.001559864],"category_scores_gemma":[0.00007878219,0.00005947133,0.0001266806,0.00009855433,0.0001059557,0.0001459053,0.00008760527,0.0004003068,0.0001852791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009112056,"about_ca_system_score_gemma":0.0001120213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001963039,"about_ca_topic_score_gemma":0.0003858103,"domain_scores_codex":[0.9999592,0.000009987919,0.000004305791,0.000008531966,0.00001013298,0.000007883023],"domain_scores_gemma":[0.9999467,0.00001669453,0.00001238441,0.000007097072,0.000006314319,0.00001082911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001359226,0.00003965305,0.0001448662,0.00003722428,0.000005290221,0.0000239318,0.00001625866,0.0000321415,0.9976578,0.00005441351,0.00003831716,0.001814173],"study_design_scores_gemma":[0.00002130811,0.0008373634,0.005351342,0.000008045597,0.00001621039,0.0002527969,0.00002928947,0.0004418099,0.9901794,0.00003713105,0.002822791,0.000002492344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912761,0.0048525,0.001945146,0.00009017411,0.00003211879,0.00002089757,0.0001580867,0.00004694198,0.001578015],"genre_scores_gemma":[0.9954417,0.001984873,0.0008260456,0.00004106059,0.000007915048,0.00001955995,0.000237775,0.000005248242,0.001435793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001559864,"threshold_uncertainty_score":0.005218208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01837326336673556,"score_gpt":0.2524957273914544,"score_spread":0.2341224640247188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}