{"id":"W3124587416","doi":"10.1200/jco.20.03579","title":"Pembrolizumab Plus Ipilimumab or Placebo for Metastatic Non–Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score ≥ 50%: Randomized, Double-Blind Phase III KEYNOTE-598 Study","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":253,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; St Mary's Hospital Centre","funders":"","keywords":"Pembrolizumab; Ipilimumab; Medicine; Internal medicine; Placebo; Lung cancer; Hazard ratio; Population; Oncology; Adverse effect; Cancer; Surgery; Immunotherapy; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002684206,0.002648483,0.003956097,0.0006256105,0.0006168367,0.001244059,0.001481016,0.002542694,0.01196654],"category_scores_gemma":[0.002407619,0.001305074,0.002240985,0.0005107321,0.001592615,0.001601943,0.0006061317,0.003930082,0.00257918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008491647,"about_ca_system_score_gemma":0.001825381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008136944,"about_ca_topic_score_gemma":0.0016626,"domain_scores_codex":[0.9990659,0.0004446074,0.00006332318,0.0002188702,0.00008327612,0.0001239706],"domain_scores_gemma":[0.9990269,0.0002548536,0.0002057404,0.00009720676,0.00008565395,0.0003295928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9741831,0.01239494,0.0001571221,0.0007480198,0.0005746893,0.0000229304,0.00002932591,0.0002013563,0.002733714,0.0001133511,0.000808113,0.008033313],"study_design_scores_gemma":[0.9621179,0.03645279,0.0003010392,0.00002195799,0.0002246886,0.00001346724,0.000006821417,0.000184356,0.0002367835,0.00008853163,0.0003443984,0.000007329258],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9473633,0.007819197,0.002982421,0.001736507,0.002367389,0.02702302,0.004500129,0.0005340097,0.005674051],"genre_scores_gemma":[0.9576671,0.005119917,0.003789606,0.002310347,0.001118318,0.02062633,0.002124137,0.00007813715,0.007166163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01196654,"threshold_uncertainty_score":0.04003215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1521484463186084,"score_gpt":0.4832800177848606,"score_spread":0.3311315714662522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}