{"id":"W3124666661","doi":"10.1016/j.ymthe.2021.01.013","title":"Three Decades of Clinical Gene Therapy: From Experimental Technologies to Viable Treatments","year":2021,"lang":"en","type":"editorial","venue":"Molecular Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Genetic enhancement; Viral vector; Stem cell; Medicine; Progenitor cell; Hematopoietic stem cell transplantation; Bioinformatics; Transplantation; Gene; Biology; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01712393,0.001287471,0.002168979,0.002164002,0.001471861,0.008110729,0.001909881,0.007628289,0.008099409],"category_scores_gemma":[0.01856097,0.0007207058,0.001210331,0.001533736,0.01250029,0.01240925,0.00498864,0.01801208,0.004235819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00432252,"about_ca_system_score_gemma":0.004176414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007108015,"about_ca_topic_score_gemma":0.000818903,"domain_scores_codex":[0.9912377,0.003218326,0.0007857109,0.0008777302,0.003312661,0.0005679464],"domain_scores_gemma":[0.9802101,0.01253356,0.0008626008,0.001670582,0.003067603,0.001655558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004017462,0.0003412393,0.0005562851,0.003643894,0.0001488102,0.0003322874,0.0009794413,0.0005698579,0.003739767,0.189698,0.3054599,0.4941288],"study_design_scores_gemma":[0.00005505512,0.0002472721,0.0002106891,0.001628725,0.0000338707,0.0004018836,0.0002642618,0.0001521186,0.001030802,0.04795288,0.9479799,0.00004267727],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"editorial","genre_scores_codex":[0.001312669,0.7263245,0.01031397,0.2146672,0.03648694,0.00006226847,0.00009627108,0.0001998674,0.01053622],"genre_scores_gemma":[0.01496331,0.7872526,0.008536426,0.1196174,0.05496204,0.0002282157,0.0002104752,0.0002661916,0.0139632],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.01712393,"threshold_uncertainty_score":0.09056103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01939982317878504,"score_gpt":0.3789756259506313,"score_spread":0.3595758027718463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}