{"id":"W3124666661","doi":"10.1016/j.ymthe.2021.01.013","title":"Three Decades of Clinical Gene Therapy: From Experimental Technologies to Viable Treatments","year":2021,"lang":"en","type":"editorial","venue":"Molecular Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Genetic enhancement; Viral vector; Stem cell; Medicine; Progenitor cell; Hematopoietic stem cell transplantation; Bioinformatics; Transplantation; Gene; Biology; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001674445,0.0004737685,0.0006959205,0.00007984535,0.00004304162,0.00003741166,0.0005862754,0.001236612,0.00003904387],"category_scores_gemma":[0.0001404792,0.0004396714,0.0004380515,0.0001372585,0.00008590573,0.000002182462,0.0002286801,0.0002756448,0.000008037435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002295701,"about_ca_system_score_gemma":0.0001919095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000121378,"about_ca_topic_score_gemma":0.0000175127,"domain_scores_codex":[0.9977136,0.00006616412,0.0005701382,0.000883493,0.0004270171,0.0003395832],"domain_scores_gemma":[0.9984371,0.00005387267,0.0001640203,0.001102849,0.0001499521,0.00009219864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002895925,0.0002878646,0.0001859547,0.000005581488,0.0009050429,0.00002890306,0.0000317957,0.00006811305,0.8963675,0.000001624298,0.08221052,0.01961751],"study_design_scores_gemma":[0.00121468,0.0007168145,0.00004715046,0.00002594462,0.00001932766,6.200472e-7,0.00002893555,0.000004128275,0.6511915,0.00003459911,0.3464373,0.000279063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"editorial","genre_scores_codex":[0.6756769,0.1316585,0.01551349,0.0000704013,0.1757995,0.0007400176,0.0003396596,0.00008916571,0.0001123964],"genre_scores_gemma":[0.4066665,0.06703084,0.04788011,0.0004800278,0.4673442,0.0009171903,0.008114639,0.0007820666,0.0007844577],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.2915447,"threshold_uncertainty_score":0.9998055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01939982317878504,"score_gpt":0.3789756259506313,"score_spread":0.3595758027718463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}