{"id":"W3124675115","doi":"10.1200/jco.2021.39.3_suppl.396","title":"Genomic characterization of <i>ATM</i> alterations in advanced pancreatic ductal adenocarcinoma (PDAC).","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Centre Hospitalier de l’Université de Montréal; McGill University Health Centre; McGill University; Princess Margaret Cancer Centre; Mount Sinai Hospital; Nova Scotia Cancer Centre; Ontario Institute for Cancer Research; Toronto General Hospital; Dalhousie University; University of Toronto; University Health Network","funders":"","keywords":"PALB2; Medicine; Genome instability; Loss of heterozygosity; Germline; MUTYH; Homologous recombination; DNA repair; Gene; Cancer research; Genetics; Germline mutation; Biology; Mutation; Allele; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002336187,0.0001144834,0.0002101025,0.0009384973,0.0001758688,0.0002619832,0.0001284317,0.0002391762,0.001099291],"category_scores_gemma":[0.0005390777,0.00008549524,0.0001365169,0.0006882915,0.0001496591,0.0001395703,0.0002722117,0.0001458644,0.0002090381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001607679,"about_ca_system_score_gemma":0.0001302316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007336785,"about_ca_topic_score_gemma":0.001054524,"domain_scores_codex":[0.9998754,0.00001797419,0.00001927276,0.00003830317,0.00002981754,0.00001914146],"domain_scores_gemma":[0.9996918,0.00006884784,0.0001079,0.00002181561,0.00003724679,0.00007232455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005595245,0.00003243348,0.9750794,0.00003866248,0.00002157073,0.001238543,0.0000767149,0.0001423736,0.0148064,0.00002679091,0.000129303,0.007848316],"study_design_scores_gemma":[0.000009119441,0.0002487666,0.9915383,0.000004243324,0.00002674446,0.004606589,0.00007888181,0.0002055594,0.002519613,0.00002247617,0.0007374918,0.000002281191],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987999,0.0002136052,0.0001060549,0.00001242931,0.000001389086,0.00001049707,0.0004936535,0.000007073792,0.000355309],"genre_scores_gemma":[0.9984574,0.0000916533,0.0003022966,0.00001496797,0.000004131743,0.000009725837,0.0009636066,0.000002893679,0.0001531773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001099291,"threshold_uncertainty_score":0.003677487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03449373534263918,"score_gpt":0.3664201265853688,"score_spread":0.3319263912427297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}