{"id":"W3124716271","doi":"10.1007/s00726-020-02938-w","title":"Transglutaminase 2: a novel therapeutic target for idiopathic pulmonary fibrosis using selective small molecule inhibitors","year":2021,"lang":"en","type":"article","venue":"Amino Acids","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Aston University; Biotechnology and Biological Sciences Research Council; York University; GlaxoSmithKline","keywords":"Myofibroblast; Idiopathic pulmonary fibrosis; Fibronectin; Extracellular matrix; Tissue transglutaminase; Cancer research; Fibrosis; Phenotype; Transforming growth factor; Fibroblast; Pulmonary fibrosis; Cell biology; Biology; Chemistry; Lung; Pathology; Medicine; Internal medicine; Biochemistry; In vitro; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001903169,0.0003821163,0.0005722115,0.0001404514,0.0002421754,0.00004931894,0.0001309592,0.0002532795,0.00006239075],"category_scores_gemma":[0.00006077238,0.0003774434,0.0005832362,0.0004605179,0.0001284716,0.0001495054,0.00005623738,0.000296585,0.00001024745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002334313,"about_ca_system_score_gemma":0.0006250504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007401759,"about_ca_topic_score_gemma":0.000006781453,"domain_scores_codex":[0.9978584,0.00007432726,0.0004596222,0.0006859457,0.0003018313,0.0006198791],"domain_scores_gemma":[0.9987446,0.0000600144,0.0001103953,0.0003811056,0.0004116637,0.0002921957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002465088,0.0008790703,0.001646698,0.0006672221,0.0002400734,0.0004123423,0.0003857869,0.00002945833,0.9888794,0.0004154207,0.00006517059,0.003914301],"study_design_scores_gemma":[0.004498905,0.007305114,0.008200921,0.001768578,0.001995618,0.001878972,0.001787261,0.01780176,0.9490722,0.0006357925,0.003761858,0.001292998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9514116,0.008477962,0.03572598,0.0007811222,0.0006214131,0.001232223,0.0004339617,0.0001816709,0.001134091],"genre_scores_gemma":[0.9930819,0.00004440323,0.004684696,0.0006977904,0.0006605559,0.0001231782,0.0001914089,0.00009862051,0.0004174166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04167035,"threshold_uncertainty_score":0.9998677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02546106968593214,"score_gpt":0.2674016746494051,"score_spread":0.2419406049634729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}