{"id":"W3124716271","doi":"10.1007/s00726-020-02938-w","title":"Transglutaminase 2: a novel therapeutic target for idiopathic pulmonary fibrosis using selective small molecule inhibitors","year":2021,"lang":"en","type":"article","venue":"Amino Acids","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Aston University; Biotechnology and Biological Sciences Research Council; York University; GlaxoSmithKline","keywords":"Myofibroblast; Idiopathic pulmonary fibrosis; Fibronectin; Extracellular matrix; Tissue transglutaminase; Cancer research; Fibrosis; Phenotype; Transforming growth factor; Fibroblast; Pulmonary fibrosis; Cell biology; Biology; Chemistry; Lung; Pathology; Medicine; Internal medicine; Biochemistry; In vitro; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001839699,0.0003836833,0.0003280312,0.0001935944,0.0001011025,0.0002854224,0.000204884,0.000393835,0.0006614468],"category_scores_gemma":[0.00005289586,0.00009322172,0.000300992,0.0001194737,0.0001456712,0.0002179547,0.0001395561,0.0005666734,0.0002152287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002312486,"about_ca_system_score_gemma":0.0001313448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002702412,"about_ca_topic_score_gemma":0.0008776694,"domain_scores_codex":[0.9999497,0.0000095689,0.000003039423,0.00001266524,0.00001289047,0.00001222292],"domain_scores_gemma":[0.9999772,0.00000417445,0.000006236995,0.000002209391,0.000003780375,0.000006328245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002240801,0.0001159453,0.0002128789,0.0002081507,0.00002798407,0.0002432995,0.00002798898,0.0002677438,0.9807491,0.0004634124,0.000301732,0.01715766],"study_design_scores_gemma":[0.0003511246,0.002722194,0.002495722,0.0000484395,0.00013306,0.002187989,0.00003855968,0.001895304,0.9499747,0.0002285968,0.03990736,0.00001687748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8859147,0.06817849,0.03345509,0.001187876,0.0003386573,0.0003326916,0.000513639,0.0004927832,0.009586058],"genre_scores_gemma":[0.9653752,0.02064354,0.008102315,0.0002766361,0.00006527259,0.00015368,0.000508813,0.00002848426,0.004846107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006614468,"threshold_uncertainty_score":0.002212703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02546106968593214,"score_gpt":0.2674016746494051,"score_spread":0.2419406049634729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}