{"id":"W3124718681","doi":"10.20944/preprints201706.0126.v1","title":"2,5-Dihydroxyacetophenone Induces Apoptosis of Multiple Myeloma Cells by Regulating the MAPK Activation Pathway","year":2017,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Population and Public Health; National Research Foundation of Korea; Ministry of Science, ICT and Future Planning; King Saud University; National Research Foundation","keywords":"DHAP; MAPK/ERK pathway; Cancer research; Apoptosis; Cyclin D1; Survivin; Kinase; Cyclin D3; Cell growth; Cell cycle; Angiogenesis; Chemistry; Cell biology; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008320926,0.0004372121,0.0002143101,0.000311698,0.0002010458,0.0001589163,0.0001310494,0.0001801364,0.00122158],"category_scores_gemma":[0.00004980223,0.00008867919,0.0002785468,0.000265974,0.0001201375,0.0001554705,0.0001672756,0.0005244514,0.0002366089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002544539,"about_ca_system_score_gemma":0.0003117473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001015371,"about_ca_topic_score_gemma":0.00159227,"domain_scores_codex":[0.999909,0.00001262781,0.000006726544,0.00001097677,0.00002717245,0.00003343725],"domain_scores_gemma":[0.9999734,0.000003406125,0.00000665573,0.000002821892,0.000005193958,0.00000845783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002423034,0.00008010245,0.000282905,0.00007690994,0.000009132572,0.00009992917,0.00001509079,0.00008268255,0.9964333,0.00007634935,0.00008284135,0.00251841],"study_design_scores_gemma":[0.00007163059,0.0007197218,0.007179083,0.00001032133,0.00002506448,0.0002771731,0.00004340784,0.00108123,0.9872437,0.0001164535,0.003225897,0.000006179234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880549,0.005987431,0.002405107,0.0002618203,0.00005670145,0.00006754869,0.0004782835,0.0001246972,0.002563612],"genre_scores_gemma":[0.9934742,0.002739433,0.001306867,0.00009407297,0.000009536045,0.00005022864,0.0003818762,0.000005662725,0.001938082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00122158,"threshold_uncertainty_score":0.004086554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05395783801819524,"score_gpt":0.2910022853574671,"score_spread":0.2370444473392719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}