{"id":"W3124741176","doi":"10.1021/acschemneuro.0c00801","title":"Radiosynthesis, <i>In Vitro</i> and <i>In Vivo</i> Evaluation of [<sup>18</sup>F]CBD-2115 as a First-in-Class Radiotracer for Imaging 4R-Tauopathies","year":2021,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Advanced Neuroimaging Techniques and Applications","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Center for Scientific Review; National Institute of Neurological Disorders and Stroke; National Institute on Aging","keywords":"Radioligand; Progressive supranuclear palsy; Radiosynthesis; In vivo; In vitro; Chemistry; Biochemistry; Biology; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005625221,0.0001705786,0.0003483163,0.0001404034,0.00004820851,0.00002288152,0.0001736571,0.00005619144,0.000008582591],"category_scores_gemma":[0.001883916,0.0001743098,0.00005921138,0.000733908,0.0002780514,0.0001913639,0.00009523651,0.0002434933,4.510371e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001004895,"about_ca_system_score_gemma":0.0001400999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001236063,"about_ca_topic_score_gemma":0.000002988968,"domain_scores_codex":[0.9980769,0.00005505467,0.0004129357,0.0006894015,0.0004153066,0.0003504408],"domain_scores_gemma":[0.9988858,0.0004204436,0.00009635102,0.0003865222,0.0001165827,0.00009430013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008567314,0.0001950968,0.003407626,0.0000697546,5.579719e-7,0.0000261753,0.00007737974,0.0001734815,0.9929448,0.00009945003,0.0001399028,0.002780068],"study_design_scores_gemma":[0.001200161,0.00002424228,0.001135826,0.0001592436,0.00002706439,0.0001644806,0.00005337959,0.07060941,0.9227431,0.001356803,0.00237904,0.0001471953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924225,0.0004542554,0.0007620458,0.004917077,0.00003116426,0.0008563603,0.00002164729,0.0000495341,0.0004854319],"genre_scores_gemma":[0.9929091,0.0002847509,0.004998176,0.001481231,0.0000271573,0.0002303951,0.000004521409,0.00002337907,0.00004123115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07043593,"threshold_uncertainty_score":0.7108147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04946250459498117,"score_gpt":0.3427965657075194,"score_spread":0.2933340611125382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}