{"id":"W3124760272","doi":"10.1186/s12967-021-02706-8","title":"Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response","year":2021,"lang":"en","type":"article","venue":"Journal of Translational Medicine","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Cancer Institute, University of Pittsburgh; U.S. Department of Veterans Affairs","keywords":"Cetuximab; Head and neck squamous-cell carcinoma; Cancer research; Epidermal growth factor receptor; EGFR inhibitors; Gefitinib; Cytokine; CXCL10; Biology; Chemokine; Interferon; Medicine; Immune system; Antibody; Immunology; Cancer; Monoclonal antibody; Internal medicine; Head and neck cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002177814,0.0002283207,0.0002139455,0.0002299457,0.0001210964,0.0003638272,0.00009680687,0.0001743427,0.00165091],"category_scores_gemma":[0.0001736277,0.00005442985,0.0002146619,0.0001448142,0.00009840493,0.0001405596,0.0001503637,0.0002925732,0.0003626865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004223339,"about_ca_system_score_gemma":0.000269334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002164995,"about_ca_topic_score_gemma":0.0003762894,"domain_scores_codex":[0.9998555,0.00002654791,0.00001338051,0.00002133852,0.00004655448,0.00003657676],"domain_scores_gemma":[0.9999182,0.00001389514,0.00002914657,0.000006036151,0.00001981611,0.00001283675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006530297,0.0001203189,0.007884175,0.0001896754,0.00002469358,0.0001061761,0.00003767455,0.0005000642,0.9699505,0.0001221354,0.0003055412,0.02010586],"study_design_scores_gemma":[0.00007363398,0.001848693,0.2226439,0.00009347723,0.0001085577,0.0009837321,0.0002592776,0.004438822,0.7589868,0.0003075915,0.01023913,0.00001627799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874708,0.00651607,0.001275378,0.0001662213,0.00003772253,0.00008551553,0.001095686,0.0000724874,0.003280108],"genre_scores_gemma":[0.9960867,0.001470503,0.0007337303,0.00006736369,0.00001011621,0.00004253249,0.0007695685,0.000006199809,0.0008133253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00165091,"threshold_uncertainty_score":0.005522788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03024307737637144,"score_gpt":0.2760019190202912,"score_spread":0.2457588416439198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}