{"id":"W3124815318","doi":"10.1021/acscentsci.0c01589","title":"7-Fluorosialyl Glycosides Are Hydrolysis Resistant but Readily Assembled by Sialyltransferases Providing Easy Access to More Metabolically Stable Glycoproteins","year":2021,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; National Research Council Canada; University of British Columbia","funders":"Canadian Glycomics Network; Natural Sciences and Engineering Research Council of Canada; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Canadian Institutes of Health Research; Leverhulme Trust; Government of Canada","keywords":"Sialic acid; Glycoprotein; Biochemistry; Glycan; Chemistry; Sialyltransferase; Sialidase; Hydrolysis; N-Acetylneuraminic acid; Neuraminidase; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000603206,0.000312565,0.000346988,0.0001380776,0.0006489136,0.0008190522,0.001195031,0.0001528791,0.0001105476],"category_scores_gemma":[0.001230309,0.0002887331,0.0001388843,0.001619803,0.0002614873,0.0001032428,0.0005122054,0.0002003665,0.00002050347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001223267,"about_ca_system_score_gemma":0.001008881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006551937,"about_ca_topic_score_gemma":0.0005867171,"domain_scores_codex":[0.9957568,0.0001430703,0.0004190665,0.001234804,0.001156129,0.001290137],"domain_scores_gemma":[0.9977169,0.00002972976,0.0001065976,0.0007768825,0.0006137748,0.0007560915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002751446,0.0001509797,0.001763231,0.00002719626,0.0000361929,0.00003946342,0.00004783825,0.0003382498,0.9938298,0.0001129258,0.001712299,0.001666695],"study_design_scores_gemma":[0.0004951238,0.0001420441,0.008057884,0.00004160873,0.00002827465,0.00001304386,0.000103901,0.0001899355,0.9589632,0.00002664035,0.03156875,0.000369586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913428,0.0008306919,0.002910898,0.003071649,0.0001325449,0.0007815553,0.0001546716,0.00004746588,0.0007277546],"genre_scores_gemma":[0.9952504,0.0001965116,0.00129856,0.001162263,0.0001500283,0.0001292437,0.0001009099,0.00003237321,0.001679695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03486658,"threshold_uncertainty_score":0.9999565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01780129762182565,"score_gpt":0.2982571795341405,"score_spread":0.2804558819123149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}