{"id":"W3124815318","doi":"10.1021/acscentsci.0c01589","title":"7-Fluorosialyl Glycosides Are Hydrolysis Resistant but Readily Assembled by Sialyltransferases Providing Easy Access to More Metabolically Stable Glycoproteins","year":2021,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; National Research Council Canada; University of British Columbia","funders":"Canadian Glycomics Network; Natural Sciences and Engineering Research Council of Canada; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Canadian Institutes of Health Research; Leverhulme Trust; Government of Canada","keywords":"Sialic acid; Glycoprotein; Biochemistry; Glycan; Chemistry; Sialyltransferase; Sialidase; Hydrolysis; N-Acetylneuraminic acid; Neuraminidase; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001538404,0.0003234201,0.0001350759,0.0001162693,0.00009663043,0.0002441674,0.0001380745,0.0002674869,0.001070028],"category_scores_gemma":[0.0001719361,0.0001505587,0.0001862156,0.0001083767,0.0002096967,0.0002407565,0.0001344885,0.0004383825,0.0003879872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002550305,"about_ca_system_score_gemma":0.000147811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004721682,"about_ca_topic_score_gemma":0.0007355568,"domain_scores_codex":[0.999923,0.00001560333,0.000004540113,0.00001532596,0.00002436816,0.00001726976],"domain_scores_gemma":[0.9998769,0.00002377362,0.00005129469,0.00001688512,0.00001196542,0.00001925405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002699562,0.000004131854,0.00006860447,0.000009697453,0.000002524603,0.00001555924,0.000006924201,0.00004345922,0.9986948,0.0001348421,0.00002090321,0.000971556],"study_design_scores_gemma":[0.000002145643,0.0000750999,0.0006686726,0.000001742912,0.000003662152,0.00009794641,0.000004811784,0.0002302174,0.9972644,0.00003275188,0.001615913,0.00000259608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836863,0.0009916887,0.01217304,0.00008593276,0.00002368365,0.00002917409,0.000263346,0.000118425,0.002628435],"genre_scores_gemma":[0.9853893,0.0009437118,0.008964061,0.00006407666,0.00001097256,0.00002717537,0.0005704656,0.00005917121,0.003971264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001070028,"threshold_uncertainty_score":0.003579557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01780129762182565,"score_gpt":0.2982571795341405,"score_spread":0.2804558819123149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}