{"id":"W3124817069","doi":"10.1093/hmg/ddaa280","title":"Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence","year":2021,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"European Research Council; Medical Research Council; National Institutes of Health; University of Bristol; Erasmus Medisch Centrum; Biotechnology and Biological Sciences Research Council; ZonMw; Wellcome Trust; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agence Nationale de la Recherche; Erasmus Universiteit Rotterdam; Joint Programming Initiative A healthy diet for a healthy life; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Economic and Social Research Council; European Commission","keywords":"dNaM; DNA methylation; Epigenome; Biology; CpG site; Genetics; Epigenetics; 1000 Genomes Project; Genome; Gene; Single-nucleotide polymorphism; Gene expression; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002086068,0.0001985185,0.0001964347,0.0001402998,0.00005540855,0.00005141236,0.0001159018,0.0001872633,0.00001398298],"category_scores_gemma":[0.0001128271,0.0002444905,0.00004444461,0.0002873576,0.00002862679,0.000006760979,0.0001305913,0.0001134528,0.000003819689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003150498,"about_ca_system_score_gemma":0.00005793896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001447202,"about_ca_topic_score_gemma":0.001603295,"domain_scores_codex":[0.9984749,0.0001818385,0.0003412924,0.0005633364,0.0001715925,0.0002670565],"domain_scores_gemma":[0.9993478,0.00001761169,0.00008015241,0.0003664971,0.00008669141,0.0001012463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001144261,0.00006913322,0.08434571,0.00001173101,0.00001294354,0.00001841123,0.001010032,0.0007431888,0.9112783,0.00008045148,0.000001266996,0.002417401],"study_design_scores_gemma":[0.0004033131,0.0000855734,0.7034698,0.00002661187,0.000009196808,2.1507e-7,0.00003037615,0.00005685891,0.2936676,0.001466157,0.0005802739,0.0002040934],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864713,0.007558437,0.005275769,0.0001283059,0.00008999,0.0003321164,0.0000239796,0.000008525922,0.0001115553],"genre_scores_gemma":[0.9954014,0.00100555,0.002821572,0.0003378215,0.0001225166,0.00004073237,0.0001986921,0.00003704826,0.00003462454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6191241,"threshold_uncertainty_score":0.9970034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01901747652520181,"score_gpt":0.2546225494285084,"score_spread":0.2356050729033066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}