{"id":"W3124817069","doi":"10.1093/hmg/ddaa280","title":"Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence","year":2021,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"European Research Council; Medical Research Council; National Institutes of Health; University of Bristol; Erasmus Medisch Centrum; Biotechnology and Biological Sciences Research Council; ZonMw; Wellcome Trust; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agence Nationale de la Recherche; Erasmus Universiteit Rotterdam; Joint Programming Initiative A healthy diet for a healthy life; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Economic and Social Research Council; European Commission","keywords":"dNaM; DNA methylation; Epigenome; Biology; CpG site; Genetics; Epigenetics; 1000 Genomes Project; Genome; Gene; Single-nucleotide polymorphism; Gene expression; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004783686,0.000146251,0.0002679062,0.0005979962,0.000211703,0.0003884407,0.0002013362,0.0002814724,0.0009837075],"category_scores_gemma":[0.001506824,0.0001649072,0.0003178244,0.0009885125,0.0001754613,0.0002055873,0.0004284939,0.0003647326,0.0001438832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002406401,"about_ca_system_score_gemma":0.0002016073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008620135,"about_ca_topic_score_gemma":0.01272593,"domain_scores_codex":[0.9996547,0.00007929047,0.00002302933,0.0001363078,0.00004584204,0.00006084899],"domain_scores_gemma":[0.9993232,0.000196088,0.0002118923,0.00008664221,0.00009934052,0.0000828043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001932462,0.00001350418,0.9867135,0.00003902606,0.0001936779,0.00005639618,0.0002631845,0.0001684595,0.006153828,0.00007911221,0.0001051239,0.006020922],"study_design_scores_gemma":[8.392042e-7,0.00001666483,0.999301,0.000002779287,0.00001674397,0.00005746886,0.00004221938,0.0000556,0.0002717656,0.00002140715,0.0002120254,0.000001515949],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996465,0.0008440832,0.0006992642,0.00004098135,0.000002865263,0.000006257595,0.001531327,0.00001116726,0.000399119],"genre_scores_gemma":[0.9969264,0.0004886961,0.0008088683,0.00002420725,0.000004086602,0.00001496674,0.001348976,0.000009832976,0.0003741043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008620135,"threshold_uncertainty_score":0.01713991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01901747652520181,"score_gpt":0.2546225494285084,"score_spread":0.2356050729033066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}