{"id":"W3124903498","doi":"10.1172/jci.insight.138382","title":"p66ShcA potentiates the cytotoxic response of triple-negative breast cancers to PARP inhibitors","year":2021,"lang":"en","type":"article","venue":"JCI Insight","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; McGill University; Occupational Cancer Research Centre; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Cancer Society; Canadian Institutes of Health Research; Cancer Research Society; McGill University","keywords":"Cancer research; Doxorubicin; Cytotoxic T cell; Poly ADP ribose polymerase; Triple-negative breast cancer; DNA damage; Genome instability; Medicine; Breast cancer; Biology; Internal medicine; Chemotherapy; In vitro; Cancer; Polymerase; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001528262,0.0002221245,0.0003193582,0.0002102835,0.0001107354,0.0002466346,0.00009454832,0.0001872733,0.002261447],"category_scores_gemma":[0.0001714929,0.00009108051,0.0001782154,0.000149686,0.0001243834,0.0001363888,0.0001972529,0.0007271934,0.0003019416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001462061,"about_ca_system_score_gemma":0.0001724406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003238725,"about_ca_topic_score_gemma":0.0007891614,"domain_scores_codex":[0.9999049,0.00001927833,0.000007326892,0.000008792772,0.0000242754,0.00003548458],"domain_scores_gemma":[0.9999179,0.00001488801,0.00001682864,0.000009503661,0.00001058539,0.00003038047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001317563,0.0004715267,0.001068515,0.0001796194,0.0000343072,0.000223917,0.00005076313,0.0003881184,0.9729319,0.0001968831,0.0009724832,0.02216441],"study_design_scores_gemma":[0.0003575212,0.01042759,0.06555171,0.00005494024,0.0001081302,0.001267496,0.0001650969,0.002952054,0.9011399,0.0003368098,0.01761738,0.0000214931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909384,0.003950736,0.0006242213,0.0003707871,0.0001568525,0.00005219677,0.0002674796,0.00008679792,0.003552321],"genre_scores_gemma":[0.9961984,0.001554127,0.0002463234,0.0001103953,0.00004609667,0.00002377851,0.0002339741,0.000006461538,0.001580553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002261447,"threshold_uncertainty_score":0.00756532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02001040109675004,"score_gpt":0.29442475160202,"score_spread":0.27441435050527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}