{"id":"W3124907493","doi":"10.1200/jco.20.01359","title":"Clinical Outcomes and Patient-Matched Molecular Composition of Relapsed Medulloblastoma","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; McGill University Health Centre; Dalhousie University; University of Toronto; BC Children's Hospital; SickKids Foundation; Hospital for Sick Children","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Genentech; Eli Lilly and Company","keywords":"Medulloblastoma; Medicine; Oncology; Internal medicine; Sonic hedgehog; Radiation therapy; Cohort; Vismodegib; Pathology; Gene; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004245834,0.0001178937,0.0003463148,0.000443338,0.0002002075,0.0002462037,0.0002270973,0.0001912489,0.000782926],"category_scores_gemma":[0.00154621,0.00007434707,0.0002482938,0.0003164855,0.0002038331,0.0002283259,0.0002864299,0.0001860981,0.0001393437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003948149,"about_ca_system_score_gemma":0.0002903305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001402693,"about_ca_topic_score_gemma":0.002302306,"domain_scores_codex":[0.999559,0.00009614276,0.00006134206,0.0001238934,0.00009553059,0.00006398194],"domain_scores_gemma":[0.9991985,0.0001032207,0.0004296007,0.00008574664,0.00006318522,0.0001198145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008226329,0.00003587869,0.9894764,0.0000148081,0.00005977771,0.0002339698,0.00006070975,0.0001319821,0.003443017,0.00002482612,0.00008628678,0.005609559],"study_design_scores_gemma":[0.00001373897,0.0003829415,0.9973184,0.000002893218,0.00002520178,0.001293328,0.0000694273,0.000144382,0.0005469343,0.00003100061,0.0001685272,0.000003067281],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993135,0.0001592377,0.00004565217,0.00001049023,0.000001297654,0.000007236475,0.0002248933,0.000003959638,0.0002337675],"genre_scores_gemma":[0.9994499,0.00003993182,0.00004308101,0.00001017666,0.000002503453,0.000006785027,0.0003957223,0.000001885723,0.00004999381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001402693,"threshold_uncertainty_score":0.002864659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06197669489408308,"score_gpt":0.4425687299906613,"score_spread":0.3805920350965782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}