{"id":"W3124959367","doi":"10.1016/j.exer.2021.108461","title":"The mgΔlpn mouse model for Marfan syndrome recapitulates the ocular phenotypes of the disease","year":2021,"lang":"en","type":"article","venue":"Experimental Eye Research","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Fibrillin; Ectopia lentis; Ciliary body; Marfan syndrome; Cornea; Mutant; Phenotype; Cilium; Ciliary processes; Microfibril; Pathology; Lens (geology); Biology; Medicine; Ophthalmology; Cell biology; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005377044,0.001562147,0.0006047399,0.002188063,0.0006222068,0.0006741777,0.0009107465,0.001773871,0.00389848],"category_scores_gemma":[0.0004756448,0.0004934523,0.0006188396,0.0005473533,0.001126069,0.0007962727,0.0008545451,0.001769733,0.001526139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005320576,"about_ca_system_score_gemma":0.0005841876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001794888,"about_ca_topic_score_gemma":0.003901146,"domain_scores_codex":[0.9993741,0.0001000547,0.000103347,0.0001532102,0.0002022286,0.00006726508],"domain_scores_gemma":[0.9993176,0.00007993358,0.000309924,0.00008891241,0.00004675825,0.0001567643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003146752,0.00007943051,0.0006459888,0.0001053254,0.00002730958,0.00159967,0.00008491164,0.0003558871,0.9913952,0.001873199,0.000435289,0.003083091],"study_design_scores_gemma":[0.0004025573,0.000771645,0.01718608,0.000203321,0.0002192604,0.01633054,0.0003537848,0.00422379,0.9216989,0.002302856,0.03621784,0.00008939904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9588559,0.002640526,0.02414517,0.001017291,0.0004941512,0.000184789,0.004343106,0.001339159,0.006980033],"genre_scores_gemma":[0.9549114,0.001794791,0.02375162,0.0003639732,0.00008920585,0.0003262977,0.002111039,0.0004363055,0.01621539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00389848,"threshold_uncertainty_score":0.01304168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04658584775883719,"score_gpt":0.3907304346701976,"score_spread":0.3441445869113604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}