{"id":"W3125015665","doi":"10.1038/s41598-020-80956-0","title":"Complexity of the eukaryotic dolichol-linked oligosaccharide scramblase suggested by activity correlation profiling mass spectrometry","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eidgenössische Technische Hochschule Zürich; University at Buffalo; University of Toronto; University of Bern; State University of New York; Weill Cornell Medical College; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Dolichol; Phospholipid scramblase; Endoplasmic reticulum; Flippase; Biochemistry; Glycosylation; Chemistry; Glycoprotein; Cell biology; Biology; Phospholipid; Phosphatidylserine; Biosynthesis; Membrane; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002472833,0.0004492707,0.000204757,0.0004999264,0.000151666,0.0005565446,0.0002576915,0.0003535281,0.0006805647],"category_scores_gemma":[0.0005243841,0.0001455211,0.0003296222,0.0002982651,0.0002035151,0.0003237376,0.0001897467,0.0003896026,0.0003867939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003036425,"about_ca_system_score_gemma":0.0002479091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005788617,"about_ca_topic_score_gemma":0.000482997,"domain_scores_codex":[0.9998516,0.00001410336,0.00001059878,0.00004464828,0.00005572611,0.0000232018],"domain_scores_gemma":[0.9997651,0.00005105652,0.00008858473,0.00002335138,0.00004477037,0.00002715336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007204006,0.000009082635,0.0009188298,0.0000282908,0.00001111169,0.0001099077,0.00001074456,0.0002200097,0.9955677,0.0002272358,0.00004803922,0.002776905],"study_design_scores_gemma":[0.000006120348,0.0001128204,0.009426315,0.00001302574,0.00002889632,0.0005429637,0.00002585388,0.00743343,0.9793156,0.0002360201,0.002847229,0.00001174375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9476131,0.002172137,0.04576514,0.000240426,0.00002900026,0.00010087,0.00121284,0.0004565413,0.002410005],"genre_scores_gemma":[0.9682088,0.0009640541,0.02744053,0.0001356381,0.00001173932,0.00003938787,0.001877036,0.00005356929,0.001269202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006805647,"threshold_uncertainty_score":0.002276719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02435360440111379,"score_gpt":0.2819971238032694,"score_spread":0.2576435194021556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}