{"id":"W3125055022","doi":"10.3390/cells10010185","title":"Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Fonds Baillet Latour; Canada Excellence Research Chairs, Government of Canada; Fonds De La Recherche Scientifique - FNRS","keywords":"Akkermansia muciniphila; Context (archaeology); Lactosylceramide; Carnitine; Endocrinology; Internal medicine; Butyrate; Metabolic syndrome; Metabolome; Pharmacology; Biology; Chemistry; Biochemistry; Medicine; Obesity; Gut flora; Metabolite; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001690578,0.0003199647,0.0004009937,0.0002109199,0.000119384,0.0002497304,0.0001219304,0.0003187733,0.0008947524],"category_scores_gemma":[0.0001749429,0.00009489987,0.0003113576,0.0001242072,0.0002464165,0.0002038973,0.0002065162,0.000498248,0.00007601667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001276222,"about_ca_system_score_gemma":0.0001399395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004200441,"about_ca_topic_score_gemma":0.0006893412,"domain_scores_codex":[0.9998906,0.00002919008,0.000009461017,0.00002372609,0.00002346768,0.00002365799],"domain_scores_gemma":[0.9998766,0.00001868917,0.00005867295,0.000010237,0.00001398206,0.00002187369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006283778,0.0003828338,0.003268268,0.0003509588,0.00008765723,0.0001477492,0.00005360541,0.00007019597,0.9756767,0.00004516414,0.00005086616,0.01358215],"study_design_scores_gemma":[0.0006992263,0.03993877,0.2966405,0.0001687733,0.0007680928,0.001099064,0.0005999036,0.001229984,0.6499355,0.0003696215,0.008497573,0.00005293945],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975761,0.001786881,0.0002789381,0.00008674598,0.00002189223,0.00001405743,0.00008170211,0.00001264065,0.0001410822],"genre_scores_gemma":[0.9969615,0.001263124,0.0009239882,0.0001077024,0.00002282401,0.00002849714,0.00009879161,0.0000032201,0.0005902622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008947524,"threshold_uncertainty_score":0.002993226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02430191927470151,"score_gpt":0.280563740280701,"score_spread":0.2562618210059995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}