{"id":"W3125055022","doi":"10.3390/cells10010185","title":"Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Fonds Baillet Latour; Canada Excellence Research Chairs, Government of Canada; Fonds De La Recherche Scientifique - FNRS","keywords":"Akkermansia muciniphila; Context (archaeology); Lactosylceramide; Carnitine; Endocrinology; Internal medicine; Butyrate; Metabolic syndrome; Metabolome; Pharmacology; Biology; Chemistry; Biochemistry; Medicine; Obesity; Gut flora; Metabolite; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004036961,0.0003451085,0.000762985,0.0002283903,0.0001270769,0.0000799743,0.0002888082,0.0002353508,0.0002345027],"category_scores_gemma":[0.0005910473,0.0002581721,0.000162193,0.001031502,0.00009296569,0.00005357686,0.0001244098,0.0005706587,0.00004451072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002223219,"about_ca_system_score_gemma":0.0008185342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007536001,"about_ca_topic_score_gemma":0.0009286,"domain_scores_codex":[0.9969593,0.0002497475,0.0004333901,0.0005935046,0.001010009,0.0007540479],"domain_scores_gemma":[0.998171,0.0001544911,0.0002175729,0.0006450686,0.000393614,0.0004182236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000662256,0.0007710282,0.007807808,0.0009321606,0.0003093664,0.003841487,0.005283476,0.0001742119,0.946621,0.0001290987,0.02890723,0.004560892],"study_design_scores_gemma":[0.005419469,0.0009698904,0.591387,0.001021463,0.0002171349,0.00009024009,0.0007924365,0.0000624133,0.3900886,0.00006041104,0.009457769,0.000433122],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712169,0.0005014195,0.000008921342,0.02553892,0.0003212942,0.001304008,0.00004225086,0.0000444008,0.001021861],"genre_scores_gemma":[0.9775447,0.00001922991,0.00005833621,0.003528274,0.0005852827,0.0001355411,0.00004142634,0.00007228935,0.01801495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5835792,"threshold_uncertainty_score":0.9999871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02430191927470151,"score_gpt":0.280563740280701,"score_spread":0.2562618210059995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}