{"id":"W3125076999","doi":"10.1158/2159-8290.cd-20-1227","title":"Mitochondrial and Metabolic Pathways Regulate Nuclear Gene Expression to Control Differentiation, Stem Cell Function, and Immune Response in Leukemia","year":2021,"lang":"en","type":"review","venue":"Cancer Discovery","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Princess Margaret Cancer Centre; University of Toronto","funders":"Canadian Institutes of Health Research; Canadian Cancer Society; Leukemia and Lymphoma Society","keywords":"Biology; Function (biology); Stem cell; Immune system; Leukemia; Gene; Gene expression; Cellular differentiation; Cell biology; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002972225,0.0005053096,0.0006879692,0.001342642,0.0002226504,0.0006416457,0.0004218635,0.0005716961,0.003414623],"category_scores_gemma":[0.0003076099,0.0001437586,0.0002572675,0.001658678,0.000357468,0.0008186197,0.0005070391,0.001064135,0.002087038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000561123,"about_ca_system_score_gemma":0.0007994639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008192026,"about_ca_topic_score_gemma":0.001585354,"domain_scores_codex":[0.9999163,0.0000149235,0.00001151561,0.00001574549,0.00003146976,0.00001003221],"domain_scores_gemma":[0.9998968,0.00003374102,0.00001611129,0.000003492269,0.00003633431,0.00001350114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007024317,0.00003687975,0.0001360438,0.01200652,0.00005535255,0.0001532715,0.00006556462,0.0003349351,0.004291101,0.008104297,0.02457387,0.9501718],"study_design_scores_gemma":[0.000009027915,0.00005313443,0.0005711896,0.001670717,0.00004538514,0.0006632374,0.00004195638,0.00005419523,0.000563252,0.002540513,0.9937772,0.00001034934],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001428509,0.9978593,0.0001709779,0.0003403568,0.0001423074,0.000004423053,0.00002444035,0.000009717064,0.001305678],"genre_scores_gemma":[0.0007833498,0.9979675,0.000196849,0.0001446507,0.00007662708,0.00000459336,0.00002982497,0.000001532643,0.0007949781],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003414623,"threshold_uncertainty_score":0.01142305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02351212214866213,"score_gpt":0.2855100487200324,"score_spread":0.2619979265713703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}