{"id":"W3125089654","doi":"10.3390/cancers13020354","title":"Ex Vivo Mitochondrial Respiration Parallels Biochemical Response to Ibrutinib in CLL Cells","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Leukemia and Lymphoma Society of Canada; CancerCare Manitoba Foundation; Research Manitoba","keywords":"Ibrutinib; Bruton's tyrosine kinase; Chronic lymphocytic leukemia; Cancer research; Pharmacology; Respiration; breakpoint cluster region; Apoptosis; Biology; Leukemia; Immunology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002435585,0.0002831125,0.0002531667,0.0002774733,0.0001850328,0.0003010796,0.0001412494,0.0003369501,0.002486782],"category_scores_gemma":[0.0001599212,0.00009493707,0.0001745082,0.0003217011,0.0002368743,0.0003274457,0.0002538648,0.0006008412,0.0003718109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002223504,"about_ca_system_score_gemma":0.0001148459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004507515,"about_ca_topic_score_gemma":0.0006700736,"domain_scores_codex":[0.9997432,0.00005164052,0.00002417512,0.00007022837,0.00005971264,0.00005105924],"domain_scores_gemma":[0.999874,0.00002494234,0.00003417507,0.00001821378,0.0000234553,0.00002512562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000404762,0.00004387503,0.001167894,0.00004904697,0.00001000441,0.00003974726,0.0000739733,0.00006974823,0.9964237,0.00005924595,0.00008403075,0.001574003],"study_design_scores_gemma":[0.00005322138,0.00126538,0.06513464,0.00002274023,0.0000427455,0.0003563975,0.0003447652,0.002257095,0.9270979,0.0002761267,0.003129813,0.00001907206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790461,0.003986004,0.008681236,0.000313879,0.00009785959,0.00005764204,0.003861975,0.0001924671,0.003762849],"genre_scores_gemma":[0.9923602,0.0009115813,0.002481966,0.0001252575,0.0000209595,0.0001039377,0.001766271,0.00002312848,0.002206694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002486782,"threshold_uncertainty_score":0.008319139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02700237757680612,"score_gpt":0.3286999075869692,"score_spread":0.301697530010163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}