{"id":"W3125089654","doi":"10.3390/cancers13020354","title":"Ex Vivo Mitochondrial Respiration Parallels Biochemical Response to Ibrutinib in CLL Cells","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Leukemia and Lymphoma Society of Canada; CancerCare Manitoba Foundation; Research Manitoba","keywords":"Ibrutinib; Bruton's tyrosine kinase; Chronic lymphocytic leukemia; Cancer research; Pharmacology; Respiration; breakpoint cluster region; Apoptosis; Biology; Leukemia; Immunology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003171446,0.0001380109,0.0002777456,0.0001495989,0.00002973026,0.00002743706,0.0001216847,0.0001625482,0.0006591917],"category_scores_gemma":[0.001032981,0.0001391588,0.00008034729,0.0006279984,0.00007988196,0.00004957242,0.00009043587,0.000234437,0.0002188698],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.04504313,"about_ca_system_score_gemma":0.02963413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006648249,"about_ca_topic_score_gemma":0.0002115928,"domain_scores_codex":[0.9981282,0.0001618129,0.000315743,0.0004857092,0.0004575705,0.0004509251],"domain_scores_gemma":[0.9987478,0.0002504968,0.00003567747,0.0005178003,0.0001346886,0.0003135806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007945408,0.00001980294,0.0000323606,0.00005240048,0.00001799055,0.0004846945,0.0005489045,0.000914471,0.9285651,0.00001818075,0.06103479,0.0003658647],"study_design_scores_gemma":[0.01469315,0.0002645294,0.0002095236,0.0002124642,0.00001754853,0.00005513716,0.0002223643,0.002381335,0.8682659,0.00002376055,0.1134737,0.0001806514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941894,0.0003154012,0.0001067478,0.001654021,0.0005055426,0.00051605,0.00001460037,0.00003546499,0.002662758],"genre_scores_gemma":[0.98656,0.00006742151,0.002174847,0.00190453,0.0007521191,0.0001028256,0.00002267529,0.00003999188,0.008375625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06029927,"threshold_uncertainty_score":0.975867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02700237757680612,"score_gpt":0.3286999075869692,"score_spread":0.301697530010163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}