{"id":"W3125103770","doi":"10.1007/s00223-020-00797-x","title":"Patient-Reported Outcomes from a Randomized, Active-Controlled, Open-Label, Phase 3 Trial of Burosumab Versus Conventional Therapy in Children with X-Linked Hypophosphatemia","year":2021,"lang":"en","type":"article","venue":"Calcified Tissue International","topic":"Clinical Nutrition and Gastroenterology","field":"Nursing","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Ottawa; Children's Hospital of Eastern Ontario; McGill University; Montreal Children's Hospital","funders":"Kyowa Kirin International; University of Ottawa","keywords":"Medicine; Hypophosphatemia; Patient-Reported Outcomes Measurement Information System; Randomized controlled trial; Physical therapy; Vitamin D and neurology; Internal medicine; Open label; Fibroblast growth factor 23; Pediatrics; Psychometrics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002964283,0.001006376,0.002193025,0.0003310197,0.0003997878,0.0007932709,0.0006515048,0.001382587,0.003985649],"category_scores_gemma":[0.003200285,0.0003703433,0.002554956,0.0004422277,0.0008184424,0.0007380223,0.0004183887,0.002993848,0.0003164752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006827436,"about_ca_system_score_gemma":0.001039255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00108857,"about_ca_topic_score_gemma":0.002587705,"domain_scores_codex":[0.9982785,0.001088133,0.0001149588,0.0001939481,0.0001555269,0.0001689946],"domain_scores_gemma":[0.997883,0.0008230924,0.0007149593,0.0001035593,0.0001064746,0.0003689151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9648632,0.006262729,0.003113416,0.001025391,0.002220309,0.00005796202,0.00008885429,0.0005759304,0.001674787,0.0001144584,0.0009837685,0.01901905],"study_design_scores_gemma":[0.882938,0.1036947,0.01036789,0.00009882532,0.001221384,0.00007986954,0.00005501969,0.0004021783,0.0004270909,0.0001472719,0.0005488484,0.00001895623],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990684,0.00474401,0.0003058901,0.0003449089,0.00009659495,0.001319889,0.001566386,0.00003707886,0.0009012863],"genre_scores_gemma":[0.9901574,0.001988679,0.001204151,0.0006162858,0.0001169852,0.003499684,0.001764099,0.0000120296,0.0006406445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003985649,"threshold_uncertainty_score":0.01567686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05799501517726069,"score_gpt":0.3803615649110709,"score_spread":0.3223665497338102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}