{"id":"W3125135564","doi":"10.1002/hon.2838","title":"Brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine in patients with advanced‐stage, classical Hodgkin lymphoma: A prespecified subgroup analysis of high‐risk patients from the ECHELON‐1 study","year":2021,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Spinal Cord Injury BC; BC Cancer Agency","funders":"Takeda Oncology","keywords":"Medicine; Dacarbazine; ABVD; Internal medicine; Neutropenia; Brentuximab vedotin; Hazard ratio; Vinblastine; Gastroenterology; Population; Febrile neutropenia; Subgroup analysis; Adverse effect; Surgery; Lymphoma; Oncology; Confidence interval; Chemotherapy; Vincristine; Hodgkin lymphoma; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001712374,0.0005138426,0.001449327,0.0004222128,0.0001641133,0.0006320757,0.0003032644,0.000405967,0.0004899052],"category_scores_gemma":[0.001236771,0.0002658698,0.002404856,0.0004756099,0.0002004228,0.0004324657,0.0003521293,0.0006050187,0.00008287943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003724189,"about_ca_system_score_gemma":0.0004188514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008230731,"about_ca_topic_score_gemma":0.002722675,"domain_scores_codex":[0.9992672,0.0003587116,0.00008235266,0.0001138758,0.00008490322,0.00009306308],"domain_scores_gemma":[0.9992281,0.0002279234,0.0002248441,0.0001221714,0.00004545336,0.0001513858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2306993,0.00152481,0.6847858,0.0005445342,0.01643735,0.0004526202,0.0002944642,0.002586416,0.01198714,0.0001156885,0.001030609,0.04954127],"study_design_scores_gemma":[0.03251093,0.03235678,0.9125444,0.00008686184,0.01237549,0.0008330156,0.0002975295,0.004228011,0.002216621,0.0003574356,0.002135211,0.00005779187],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983725,0.001190559,0.00006992991,0.0000328731,0.00001102356,0.00003191102,0.0001568798,0.000002879657,0.0001313687],"genre_scores_gemma":[0.9989611,0.0002873466,0.00008638397,0.00005360286,0.00002862087,0.00002654587,0.0004592602,0.000002117619,0.00009505127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001712374,"threshold_uncertainty_score":0.009055972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0133778787264279,"score_gpt":0.2685635926708242,"score_spread":0.2551857139443963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}