{"id":"W3125135564","doi":"10.1002/hon.2838","title":"Brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine in patients with advanced‐stage, classical Hodgkin lymphoma: A prespecified subgroup analysis of high‐risk patients from the ECHELON‐1 study","year":2021,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Spinal Cord Injury BC; BC Cancer Agency","funders":"Takeda Oncology","keywords":"Medicine; Dacarbazine; ABVD; Internal medicine; Neutropenia; Brentuximab vedotin; Hazard ratio; Vinblastine; Gastroenterology; Population; Febrile neutropenia; Subgroup analysis; Adverse effect; Surgery; Lymphoma; Oncology; Confidence interval; Chemotherapy; Vincristine; Hodgkin lymphoma; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001865193,0.0003587554,0.00186421,0.0001580925,0.00008816543,0.00001816292,0.0001565996,0.0002559416,0.0002037854],"category_scores_gemma":[0.0005580991,0.0001982454,0.0001653167,0.001036199,0.0002585772,0.00005799122,0.0002751891,0.0002241853,0.000006784645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004138312,"about_ca_system_score_gemma":0.0002091673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000477788,"about_ca_topic_score_gemma":0.002096828,"domain_scores_codex":[0.9968079,0.0005832513,0.0008317492,0.0008473505,0.000517333,0.0004124223],"domain_scores_gemma":[0.9966564,0.001856282,0.0004402359,0.0005710644,0.0002897727,0.0001862325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003751106,0.02109145,0.9615647,0.00001723558,0.001506208,0.0005437651,0.0003976571,0.00004877666,0.0000100029,0.0002701522,0.0001287941,0.0106702],"study_design_scores_gemma":[0.04238446,0.005688313,0.9479214,0.00005395979,0.002419426,0.000006432897,0.0004341684,0.0002139848,0.0002145636,0.00004456614,0.000435139,0.0001835668],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974364,0.000410108,0.00003004707,0.0004624007,0.00008648419,0.001121697,0.0001751774,0.00003262304,0.0002450795],"genre_scores_gemma":[0.9979759,0.000129102,0.0009423158,0.0002798637,0.00002288806,0.0001807008,0.0004196858,0.00001937051,0.00003017788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03863336,"threshold_uncertainty_score":0.8084211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0133778787264279,"score_gpt":0.2685635926708242,"score_spread":0.2551857139443963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}